Diphenylhydantoin drug interactions

CI2. Cucinell, S. A., Conney, A. H., Sansor, M., and Bums, J. J., Drug interactions in man lowering effect of phenobarbital on plasma levels of dicoumarol and diphenylhydantoin. Clin. Pharmacol. Thcr. 6, 420-429 (1965). 

Cucinell SA, Conney AH, Sansur H Bums JJ. Drug interactions in man I. Lowerm effect of phenobarbital on plasma levels of bishydroj coumarin (Dicumarol) and diphenylhydantoin QDilantin). Clin Pharmacol Ther (1965) 6,420-9. 

Windorfer A, Sauer W, Drug interactions during anticonvulsant therapy in childhood diphenylhydantoin, primidone, phenobarbitone, clonazepam, nittazepam, carbamazepin and dipro-pylacetate, Neuropadiatrie (1977) 8,29-41,... 

A clinically important example of microsomal enzyme inhibition is the interaction between the drugs isoniazid and diphenylhy dan loin. Termination of the pharmacological activity of diphenylhydantoin depends on microsomal metabolism (figure 7.54). This may be inhibited... 

Another cause of toxicity with diphenylhydantoin can be the result of interactions with other drugs such as isoniazid. This drug is a noncompetitive inhibitor of the aromatic hydroxylation of diphenylhydantoin. Consequently, the elimination of diphenylhydantoin is impaired in the presence of isoniazid, and the plasma level is greater than anticipated for a normal therapeutic dose. Furthermore, it was found that there was a significant correlation... 

A relevant example of a suitable ionophore is the antibiotic valinomycin, which specifically binds K. Other ionophores have been developed for measurement of, for example, NHj, Ca, Cl . In addition, electrodes have been developed for organic species by using specific ion-pairing reagents in the membrane that interact with ionic forms of the organic compound, e.g. with drugs such as 5,5-diphenylhydantoin. 

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