Diphenylarsinic acid

The Bart reaction can be carried a stage further. For example, dichloro-phenylarsine, CjHjAsCl, when added to an excess of sodium carbonate solution, gives CjHjAsfONa) this solution, if similarly treated with benzenedia-zonium chloride, affords diphenylarsinic acid, (CjHjjjAsf. OjOH. 

It is possible to arylate arylarsonic acids a second time with an arenediazonium salt. The product Ar2As(0)0H is called diphenylarsinic acid. 

CisHieAs20 Fhenylene-l,2-diphenylarsinic acid (o Aminodiphenylarsinic acid) 28% 222... 

Kato, K., Mizoi, M., An, Y., Nakano, M., Wanibuchi, H., Endo, G., Endo, Y., Hoshino, M., Okada, S., Yamanaka, K. (2007). Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar Purkinje cells. Life Sci. 81 1518-25. 

Ishii, K., Tamaoka, A., Otsuka, F., Iwasaki, L, Shin, K., Matsui, A., Endo, G., Kumagai, Y., Ishii, T., Soji, S., Ogata, T., Ishi-zaki, M., Doi, M., Shimojo, N. (2004). Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan. Ann. Neurol. 56 741-5. 

A rather curious method of obtaining triphenylarsine consists in the reduction of diphenylarsinic acid with phenylhydrazine 11... 

Diphenylarsenic chloride, (CgH5)2AsClg. — This substance results when diphenylchloroarsine is treat with dry chlorine. It crystallises from dry benzene in colourless plates, M.pt. 174° C., and is decomposed by water, forming hydrochloric and diphenylarsinic acids. When heated in a sealed tube at about 200° C. it decomposes according to the equation ... 

Watson has discussed the polarographic behaviour of phenyl arsonic acid , phenyl arsenooxide , triphenylarsenooxide and diphenylarsinic acid . 

Similarly, in 0.1 M hydrochloric acid or at pH 5.3 resolution from the wave of triphenylarsine oxide is not possible. At pH > 7 only the latter species is active. Thus, by choice of a suitable pH, specific determination of phenylarsonic acid, diphenylarsinic acid and triphenylarsineoxide in mixtures is possible. Inorganic arsenic(V) is electroinactive while the tetraphenylarsonium ion is reduced at much more negative potentials. Arsenic(III) species are reduced at more positive potentials. Polarography is thus of value for the quantitative speciation of organoarsenic samples. 

A qualitative study of the effect of the position of the nitro groups in bis(nitro-phenyl)arsinic acids on the potential of the second wave has been reported . Like the nitrophenylarsonic acids, the reduction of nitro-substituted diphenylarsinic acids takes place in two distinct steps. The first reduction wave corresponds to reduction of the nitro... 

Arsinic acids and arsine oxides may be prepared by extensions of the Bart synthesis. Thus, diphenylarsinic acid is obtained from benzene- diazonium chloride and disodium phenylarsenite. 

Watson " investigated the effect of a surface-active agent by recording the current-potential curve for 2 x diphenylarsinic acid in 0.1 M hydrochloric acid in the... 

Of the diarylarsinic acids only the unsubstituted diphenylarsinic acid has been studied in detail by polarography in buffered aqueous solution" . The reduction is associated with adsorption as indicated by a prewave and a polarographic maximum on the main wave which, however, could be suppressed by addition of Triton X-100" . The height of the reduction wave is directly proportional to the concentration of Ph2 AsO(OH) in the range lO -lQ- M, and the limiting current (ij) is almost entirely diffusion-controlled". Similar conclusions were drawn for a series of bis(aminophenyl)arsinic acids based on measurements of ij as a function of the concentration and the height of the mercury column ... 

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