3-heptanone, 6- -4,4-diphenyl

Chemical Name 6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride Common Name Amidone hydrochloride Structural Formula r a. nicho,... 

Amidone (6-dimethylamino-4,4-diphenyl-3-heptanone), while resistant to hydrogenation with Raney nickel, could be hydrogenated to the alcohol with platinum oxide as catalyst.140 However, isoamidone (6-dimethylamino-4,4-diphenyl-5-methyl-3-hexanone)(15, R = Me) did not absorb hydrogen in the presence of platinum oxide and the reduction to the corresponding alcohol was achieved by reduction with lithium aluminum hydride.141... 

Ifenprodil (= l-Methyl-2-hydroxy-2-(4-hydroxyphenyl) ethyl-1 -(4-benzyl-piperidine)] -(aryl piperidine) [at(/o-3-(Indol-2-yl)-8-methyl-8-azabicyclo-[3.2.1] octane] (indolotropane) [Kynurenic acid (= 4-Hydroxy-2-quinolinecarboxylic acid)] (quinoline carboxylic acid) [Memantine (= 1-Amino-3,5 dimethyladamantane)] (amino adamantane, amino cyclic aliphatic) [Methadone (= 6-Dimethylamino-4,4-diphenyl-3-heptanone)] (aryl tertiary amine) [em/o-3-(l -Methylindol-2-yl)-8-methyl-8-azabicyclo-[3.2.1] octane(indolotropane) exo- 3-( 1 -Methylindol-2-yl)-8-methyl-8-... 

Methadone (= 6-Dimethylamino-4,4-diphenyl-3-heptanone)] (aryl tertiary amine) Synthetic O-R agonist (NMDA-Glu-R) [analgesic, narcotic]... 

For some carbonyl compounds, a reverse in optical rotation sign has been observed when the ORD spectra were measured in solvents of different polarity. For example, (5)-5-hydroxy-l,7-diphenyl-3-heptanone is dextrorotatory in trichloromethane (molar optical rotation [interaction between the y9-ketol moiety and the solvent is responsible for the change and reversal in optical rotation with increasing solvent polarity. 

SYNS 1-6-DIMETHYLAMINO-4.4-DIPHENYL-3-HEPTANONE HYDROCHLORIDE LEVADOKE LEVOTHYL POLAMIDON... 

Uethadone Hydrochloride, USP, Methadone hydrochloride. 6-(Dimethylamino)-4.4-diphenyl-3-heptanone hy-dnK hloride (Dolophine Hydrochloride), occurs as a bitter, white crystalline powder. It is soluble in water, freely soluble in alcohol and chloroform, and insoluble in ether. Methadone IS synthesized in several ways. The method of Easton et al. is noteworthy, in that it avoids the formation of the troublesome i.someric intermediate aminonitriles. The analgesic effect and other morphine-iike properties are exhibited chiefly by the (-) form. Aqueous solutions are stable and may be sterilized by heat for intramuscular and intrave-noas use. Like all amine salts, it is incompatible with alkali and salts of heavy metals. It is. somewhat irritating when injected subcutaneously. 

Isbell H, Wilker A et al (1948) Liability of addiction to 6-dimethylamino-4-4-diphenyl-3-heptanone (methadon, amidone or 10820) in man experimental addiction to methadon. Arch Intern Med (Chic) 82 362-392... 

A mixture of 6-dimethylamino-4,4-diphenyl-3-heptanone, KOH, and triethylene glycol refluxed 4 hrs. at a bath temp, of 220-230°, and the reaction product isolated as picrate -> 3-dimethylamino-l, 1-diphenyl-butane pierate. Y 90%. (E. L. May and E. Mosettig, J. Org. Chem. 13, 459 (1948).)... 

Methadone hydrochloride 6-(Dimethylamino)-4,4- diphenyl-3-heptanone hydrochloride C21H28CINO 1096-90-6 346.906 pi (al-eth) 236 vs HjO, FtOH... 

Synonyms 6-Morpholino-4,4-diphenyl-3-heptanone heptazone morphodone... 

The mechanism of photo-oxidative degradation of polystyrene was also investigated using low molecular compounds such as benzene 3-phenyl-pentane [1356] 2-phenylbutane [1360, 1361] 1,3-diphenylpropane-l-one [719, 725] 1,3-diphenylpropane 1,3-diphenylbutane 2,4-diphenylpentane [1293] cumene cumene hydroperoxide [759] acetophenone hexanoic acid 3-heptanone y-valerolactone 2-phenyl-2-propanol [1250, 1397] benzal-dehyde benzoic acid l-3-diphenyl-propanone-3 l,3-diphenyl-buten-2,3-on-l (dypnone) l,3-diphenylpropen-2,3-on-l (chalcone) l-phenyl-butanedion-2,3 l-diphenylpropanedion-1,2 l-phenyl-butanedion-1,3 phenylacetic aldehyde l,5-diphenyl-pentanone-3 4-phenyl-butanone-2 [1250]. 

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