2,5-Dioxo-7-nitro-3,4-dihydro

H, 0 0 H5C2 CO konz. konz. 0-3 2,5-Dioxo-7-nitro-3,4-dihydro-lH-1.3-bertzodiazepin 60 260 (DMF/ Methanol) 2... 

Methyl 6-methyl-7-nitro-2,3-dioxo-l,2,3,4-tetrahydro-5-quinoxalinecarboxylate Methyl 4-methyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate 2-Methyl-3-( 1 -methylprop-1 -enyl)quinoxaline Methyl 3-methyl-2-quinoxalinecarboxylate... 

The slurry was filtered, and the compound was isolated as a white solid (75.5% yield based on (la,5a,6a)-3-N-benzyl-6-nitro-2,4-dioxo-3-azabicyclo[3.1.0]hexane 96.6% based on ethyl 7-chloro-l-(2,4-difluorophenyl)-6-fluoro-l,4-dihydro-4-oxo-l,8-naphthyridine-3-carboxylic acid). The ethyl (la,5a,6a)-7-(6-benzylidenylamino-3-azabicyclo[3.1.0]hex-3yl)-l-(2,4-difluorophenyl)-6-fluoro-l,4-dihydro-4-oxo-l,8-naphthyridine-3-carboxylate was recrystallized from acetonitrile, melting point 148°-155°C decomp. 

Ethyl l-(2-chloroethyl)-6-nitro-4,7-dioxo-l,4,7,8-tertahydro- gave ethyl 7-chloro-1 -(2-chloroethyl)-6-nitro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-car-boxylate (13) [POCl3, Me2NCHO (i.e., a Vilsmeier reagent), 65°C 82%].1029... 

Furan 2-Aminomethyl-5-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidino)-2,5-dihydro- IV/lc, 578 Imidazo(l,2-a]pyridin 1,5-Dimethyl-8-nitro-7-oxo-l,2,3,7-tetrahydro-E15/3, 2790 [cycl. (R2N)2C = CH-N02 4- Diketen] 1,3-Oxazol 4-Cyan-5-(diethoxy-methylen-amino)- E4, 565 (Het — NH2 + Orthoester) Pyrazin 3-Amino-2-methoxycarbo-nyl-5-propanoyl- E9b/2, 324 (H - CO-R)... 

Benzofuran 2-Acetyl-5(bzw. 6)-nitro- E16d, 278 (H - N02) Essigsaure Phthalimido- XI/2, 314 Indol 7-Carboxy-2,3-dioxo-4-methyl-2,3-dihydro- VII/4, 16 Naphthalin... 

Pyrimidin 6-Amino-2,4-dioxo-3-phenyl-l,2,3,4-tetrahydro- E15/2, 2228 [ —R—OH(Cyclokond.)] lH- 6-Nitro-2,3-dihydro- IV/la, 182 Quinolin 4-Hydrazino-6,7-methylen-dioxy- E16a, 700 (Cl - NH-NH2) Quinolin-l-oxid 2-Amino-3-aminocarbonyl- E7a, 504 [2-N02 - Ar -CH = C(CN) -CO —NH2/Pt]... 

Cacotheline (2,3-dihydro-4-nitro-2,3-dioxo-9,10-secostrychnidin-10-oic acid) [561-20-6] M 508.4, pKEst(i)-4.4 (CO2H), W Yellow crystals from H2O. It is then dried... 

Dioxo-3-ethyl-l, 5,6,7-tetrahydro- 677 Pyrazolo[3,4-d]-l, 3-oxazin l,3-Dimethyl-4-oxo-6-(2-oxo-propyl)-dihydro- 557 1- Acyl-3-methylthio-6-oxo-l,6-dihydro- 676 2- Benzyl-6-(4-nitro-phenyl)-4-oxo-2,4-dihydro-676 4-Amino-7-chlor-phenyl- 976 2-(4-Aminosulfonyl-phenyl)-4,7-dichIor- 977 2-(4-Aminosulfonyl-phcnyl)-4,7-dihydroxy- 922 4-Anilino-7-chlor-2-(3-thienyl)- aus 4,7-DichIor-2-(3-thicnyI)- pyriclazino-[4,5-d]-l,3-thia7.ol)/Ethanol 976 7-Chlor-4-ethoxy-2-methyl- 972 7-Chlor-4-methoxy-2-phenyl- 972 7-ChIor-4-(3-pyrroIidino-propyloxy)-2-(2-thienyI)- 972... 

Ausgehend von den stereoisomeren Hydroxamsauren werden durch Alkylierung der Na-trium-Salze Carbonsaure-alkoximid-alkylester erhalten [vgl. Bd. X/4, S. 199, 750 (1968) zur Konstitutionsaufklarung s. a. Lit,97 100]. Als EjZ-Isomeren-Gemisch erhalt man 2-Hydroximino-2,3-dihydro-furane, z.B. aus 5,5-Dimethyl-l,3-dioxo-cyclohe-xan mit co-Nitro-styrol101 V81 l02 ... 

Ethoxycarbonyl-5,7-dimethyl-8-nitro-4-oxo-3,4-dihydro-1-phthalazinec ar-boxylic acid (92) underwent reduction to its 8-amino analog followed by spontaneous cyclization to afford ethyl 4,6-dimethyl-3,8-dioxo-2,3,7,8-tetra-hydropyrrolo[4,3,2-tie]phthalazine-5-carboxylate (93) (H2, Pd/C, EtOH,... 

A pendent mercury drop electrode has been used to reduce the 4,5-azomethine group in 1,4-benzodiazepines There were additional contributions from partial reduction of nitro moieties, as in nitrazepam, and A -oxides, as in chlordiazepoxide. The 5-lipoxygenase inhibitor methyl 2-[(3,4-dihydro-3,4-dioxo-l-naphthalenyl) aminojbenzoate (CGS 8515) has been measured in ethyl acetate extracts of plasma from animals treated with the drug using an ODS-modified silica column with methanol-aq. acetate buffer (0.15 mol L, pH 4.5) (60 -f 40) as eluent and EC... 

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