1.3- Dioxepin copolymers, maleic

A sample of poly (2,2-diraethyl-4,7-dihydro-l,3-dioxepin-alt-maleic anhydride) polymers was fractionated and briefly examined for antiviral properties (31). The copolymer was fractionated through Amicon filters into a 1,000-10,000 and 10,000-30,000 molecular weight cuts. Both molecular weight fractions were examined for effect against mice inoculated (ip) with 106 Ehrlich Ascites tumor cells. Five days after inoculation the animals were sacrificed and total peritoneal exudate cells were counted with a hemo-cytometer. Under these conditions, Ottenbrite (31) showed that the 1,000-10,000 molecular weight fraction of the ID-MA copolymer was as effective as Pyran (control in experiment) for control of Ehrlich Ascites tumor cells. Pyran, the copolymer of divinyl ether-MA is a well known antitumor agent (32) and interferon inducer (33). 

Uglea, C. V, Ottenbrite, R. M., Offenberg, H., Grecianu, A., and Negulescu, 1.1., Anesthesine modified maleic anhydride cyclohexyl-l,s-dioxepine copolymer. Preparation and potential medical application, 12th Annual Int. Conf. Eng. Med. Biol. Soc., Philadelphia, 1990. 

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