7,12-Dimethylbenz anthracene DMBA induced skin tumors

And, many compounds which showed strong inhibitory effects on the induction of EBV-EA by TPA have been shown to act as inhibitors of tumor promotion on two-stage carcinogenesis test in vivo [15-21, 27-29]. The one of two-stage carcinogenesis test is on mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a... 

Recently, we found that EPR effect is further enhanced by applying nitroglycerin ointment onto the skin of superficial tumors including breast cancer induced by chemical carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) in rats, and also transplanted mice tumors (Seki and Maeda, in preparation). The increase of Evans blue/albumin delivered into the solid tumors was 2- to 3-fold of that without nitroglycerin [68]. 

Topical application of the compound juglone to mice promoted skin tumors induced with the carcinogen DMBA (7,12-dimethylbenz[fl]anthracene) (Monks et al. 1990 Van Duuren et al. 1978), although no tumors were observed in mice treated with juglone alone (Van Duuren et al. 1978). 

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