2- -5-dimethylaminophenol

For cyanide and cyanogen, antidote should be administered as soon as possible. The Lilly Cyanide Antidote Kit contains amyl nitrite, sodium nitrite, and sodium thiosulfate. Cobalt edentate or 4-dimethylaminophenol are alternative antidotes for cyanide poisoning. Benzodiazepines or barbiturates may be required to control severe seizures. 

Christel, D., P. Eyer, M. Hegemann, M. Kiese, W. Lorcher, and N. Weger. 1977. Pharmacokinetics of cyanide in poisoning of dogs, and the effect of 4-dimethylaminophenol or thiosulfate. Arch. Toxicol. 38 177-189. 

Klimmek R, Roddewig C, Fladerer H, et al. 1983. Effects of 4-dimethylaminophenol, Co2EDTA, or NaN02 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning. Toxicology 26 143-154. 

Kruszyna R, Kruszyna H, Smith RP. 1982. Comparison of hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide poisoning in mice. Arch Toxicol 49 191-202. 

RCM with Schrock catalyst, 28 synthesis, 28-29 yield optimization, 40-41 (l->4)-P-0-Disaccharides, 24/ 4-DMAJP (4-dimethylaminophenol),... 

Dimethylaminophenol cyanmethemoglohin. In the presence of sodium thiosulfate cyanide is excreted as thiocyanate... 

Weger, N.P. (1983). Treatment of cyanide poisoning with 4-dimethylaminophenol (DMAP) - experimental and clinical overview. Fundam. Appl. Toxicol. 3 387-96. 

DinitTo-4-dimethylaminophenol, purple-colored ndls having a copper luster (from ale), mp 182-83° (Ref 4, pl90)... 

Sulfur Donors. These enhance the endogenous sulfurtransferase mechanisms for the detoxification of CN to SCN. Sodium thiosulfate is often used in combination with other antidotes having different modes of antidotal action for example, with sodium nitrite or 4-dimethylaminophenol (4-DMAP). As a generalization, sodium thiosulfate is used as a supplementary treatment on the basis that it is slow acting, possibly due to limited penetration into mitochondria. 

Sodium nitrite 4-Dimethylaminophenol Dicobalt edetate Hydroxocobalamin... 

Klimmeck, R., Faderer, M., and Weger, N., Circulation, respiration and blood homeostasis of dogs during slow cyanide poisoning and after treatment with 4-dimethylaminophenol or cobalt compounds. Arch. Toxicol., 3, 121-133, 1979. 

Indirect complex and capture agents Methemoglobin formers Sodium nitrite Amyl nitrite 4-Dimethylaminophenol 4-Aminopropriophenone... 

Methylacrylonitrile is a mild skin and eye irritant. However, it is readily absorbed by skin. It showed delayed skin reaction. In mice, the lethal dose from intraperitoneal administration was 15 mg/kg. The oral toxicity due to this compound was also relatively high an LD50 of 11.6 mg/kg was determined in mice. There is no report of its mutagenic, teratogenic, or carcinogenic actions in animals or humans. 4-Dimethylaminophenol [616-60-3] plus sodium thiosulfate or N-acety Icy stein [616-91-1] was shown to antagonize the acute toxicity of methylacrylonitrile (Peter and Bolt 1985). 

Dimethylaminophenol (4-DMAP), p-amino-propiophenone (PAPP), p-aminoheptanoylphenone... 

DKIE Decontamination Kit, Individual Equipment Dlco lung diffusing capacity for carbon monoxide DM diphenylaminearsine, also called adamsite 4-DMAP 4-dimethylaminophenol... 

---