4-Dimethylaminophenol, cyanide poisoning

For cyanide and cyanogen, antidote should be administered as soon as possible. The Lilly Cyanide Antidote Kit contains amyl nitrite, sodium nitrite, and sodium thiosulfate. Cobalt edentate or 4-dimethylaminophenol are alternative antidotes for cyanide poisoning. Benzodiazepines or barbiturates may be required to control severe seizures. 

Klimmek R, Roddewig C, Fladerer H, et al. 1983. Effects of 4-dimethylaminophenol, Co2EDTA, or NaN02 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning. Toxicology 26 143-154. 

Kruszyna R, Kruszyna H, Smith RP. 1982. Comparison of hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide poisoning in mice. Arch Toxicol 49 191-202. 

Weger, N.P. (1983). Treatment of cyanide poisoning with 4-dimethylaminophenol (DMAP) - experimental and clinical overview. Fundam. Appl. Toxicol. 3 387-96. 

Klimmeck, R., Faderer, M., and Weger, N., Circulation, respiration and blood homeostasis of dogs during slow cyanide poisoning and after treatment with 4-dimethylaminophenol or cobalt compounds. Arch. Toxicol., 3, 121-133, 1979. 

Bhattacharya R. 1995. Therapeutic efficacy of sodium nitrite and 4-dimethylaminophenol or hydroxylamine coadministration against cyanide poisoning in rats. Human Experimental Toxicology 14 29-33. 

Christel, D., P. Eyer, M. Hegemann, M. Kiese, W. Lorcher, and N. Weger. 1977. Pharmacokinetics of cyanide in poisoning of dogs, and the effect of 4-dimethylaminophenol or thiosulfate. Arch. Toxicol. 38 177-189. 

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