3- Dimethylamino-2- propenoate

Nitrosation of methyl 2-acylamino-3-(dimethylamino)propenoates 494 obtained from the corresponding oxazolones 493 effects the conversion of A -acylglycines to 5-substituted-l,2,4-oxadiazole-3-carboxylates 496 as shown in Scheme 7.157. ... [Pg.235]

Heteroarylamines, for example 1195, react with (dimethylamino)propenoate 1196 to yield an imidazolecarboxylate 1199. The imidazole ring is formed via the intermediate diaminoalkenoate 1197, which undergoes an intramolecular Michael addition followed by a retro-aldol-like reaction (Scheme 294) <1998JHC1527>. Similarly, 4-dimethyl-amino-2-aza-l,3-dienes 1200, serving as y-dielectrophiles, condense with amines or hydrazines neat at 70 °C to form A -substituted imidazole-4-carboxylates 1201 in 60-75% yields (Scheme 294) <1999TL8097>. [Pg.296]

Syntheses of heterocycles from alkyl 3-(dimethylamino)propenoates and related enaminones 04CRV2433. [Pg.168]

Further examples have been added to the range of 2-amino substituted 3-dimethylamino-propenoates which are of value in the synthesis of 2//-pyran-2-ones and other heterocycles <93PHC34,97JHC247, 263, 813>. [Pg.300]

Various thiazolo-heterocyclic compounds (xi) as novel MCH IR antagonist (MCH-1 receptor) have also been effectively synthesized by Guo et al. [12]. The reaction involved the microwave assisted condensation of a-heteroarylamines (ix) with 3-dimethylamino-2-aryl-propenoates (x). [Pg.17]

Compound 6 reacts with DMFDMA in boiling DMF to give ethyl (E)-3-(dimethylamino)-2- (Z)-4-[(dimethylamino)methylidene]-4,5-dihydro-5-oxo-lH-pyrazol-3-yl propenoate (9) in 70% yield. Fortunately, annular N-methylation did not take place (Scheme 4). [Pg.148]

Substituted 2,3,5,6,7,8-hexahydrop5rrazolo[4,3-d] [1,2]diazepine-8-car-boxylates 30 were obtained from ethyl (2E)-3-(dimethylamino)-2- (4Z)-4-[(dimethylamino)methylidene]-5-oxo-l-phenyl-4,5-dihydro-lH-pyra-zol-3-yl propenoate (19) via substitution of both dimethylamino groups... [Pg.155]

Ethyl (2E)-3-(dimethylamino)-2-(5-ethoxy-l-phenyl-lH-p)u-azol-3-yl)pro-penoate (36) with various N- and C-nucleophiles gave ethyl (2 )-2-(5-ethoxy-l-phenyl-lH-pyrazol-3-yl)-3-(substituted amino)propenoates 37, fused pyrazol-3-yl-pvrimidinones 38, 39 and fused pyrazol-3-yl-pyra-nones 40, 41 (05H207). [Pg.156]

The dimethylamino group in diethyl (2 R=Et) and dimethyl 1-dimethylamino-3-oxobut-l-ene-2,4-dicarboxylates (2 R=Me) can be exchanged very easily with nitrogen nucleophiles. With primary amines in methanol or ethanol under reflux for several hours, substitution of the dimethylamino group by an amine takes place followed by intramolecular nucleophilic attack of the amino group on the ester to afford 1-substituted 5-alkoxycarbonyl-4-hydroxypyridin-2(lH)-ones 56 in 16-93% yields (5cheme 21). In the reaction of 56 with methyl (Z)-2-benzoylamino-3-dimethylaminopropenoate (57), first the intermediate 58 was formed, which cyclized into 6-substituted 3-benzoylamino-8-ethoxycarbonyl-2H,5H-pyrido[4,3-li]pyran-2,5-diones (59). However, with 3-dimethyla-mino-2-(methoxycarbonyl)propenoate (60) intermediate 61 is formed... [Pg.161]

Dimethyl acetone-l,3-dicarboxylate (1) reacts with benzamidine to form methyl 2-(6-hydroxy-2-phenylpyrimidin-4-yl)acetate (72). With DMFDMA in refluxing toluene the reactive methylene group of 72 was transformed into an N,N-dimethylaminomethylidene derivative. While methylation of the hydroxyl group was taking place to give methyl (E)-3-(dimethylamino)-2-(6-methoxy-2-phenylpyrimidin-4-yl)propenoate (73) (Scheme 24). [Pg.165]

CAS 2439-35-2 EINECS/EEINCS 219-460-0 Synonyms Acrylic acid, 2-(dimethylamino) ethyl ester 2-Dimethylamino-ethyl acrylate 2-Propenoic acid, 2-(dimethylamino) ethyl ester Empirical CjHbNOj Formula CH2=CHCOOCH2CH2N(CH3)2... [Pg.1082]

Synonyms 2-(Dimethylamino) ethanol methacrylate 2-(Dimethylamino) ethyl ester methacrylic acid 2-(Dimethylamino) ethyl methaci ate p-Dimethylaminoethyl methacrylate N.N-Dimethylaminoethyl methacrylate 2-(Dimethylamino) ethyl 2-methyl-2-propenoate DMAEMA Classification Amine monomer aliphatic ester amine Empirical CiFlisNOi... [Pg.1083]

Dimethylamino) ethyl 2-methyl-2-propenoate. See Dimethylaminoethyl methacrylate... [Pg.1083]

Propanone oxime. See Acetone oxime Propathene. See Polypropylene Propenamide 2-Propenamide. See Acrylamide 2-Propenamide, N-(3-(dimethylamino) propyl)-2-methyl-. See Dimethyl amlnopropylmethacrylamide 2-Propenamide, homopolymer. See Polyacrylamide Propenamide, polymer with propenoic acid, butenoic acid, and/or alkyl propenoates. SeeAcrylates/acrylamlde copolymer 2-Propen-1-aminium, N,N-dimethyl-N-2-propenyl-, chloride. See Dimethyl diallyl ammonium chloride Propeneacid. See Acrylic acid 1-Propene, homopolymer. See Polypropylene... [Pg.1319]

Propenoic acid, 2-(dimethylamino) ethyl ester. See Dimethylaminoethyl acrylate... [Pg.1319]

Trade Name Synonyms Jeffcat ZR-70 [Huntsman http //www.huntsman.com] Dimethylaminoethyl acrylate CAS 2439-35-2 EINECS/ELINCS 219-460-0 Synonyms Acrylic acid, 2-(dimethylamino) ethyl ester 2-Dimethylaminoethyl acrylate 2-Propenoic acid, 2-(dimethylamino) ethyl ester Empirical C7H13NO2 Formula CH2=CHCOOCH2CH2N(CH3)2 Properties Colorless to si. brn. liq. sol. in water, alcohol, ethyl acetate, benzene m.w. 143.19 dens. 0.943 f.p. -75 C m.p. -55 C b.p. 64 C (12 mm) flash pt. 58 C ref. index 1.4380 (20 C) Toxicology LD50 (oral, rat) 455 mg/kg LC50 (inh., rat, 4 h) 66 mg/m highly toxic poison by inh. mod. toxic by ing. corrosive severe skin and eye irritant harmful if swallowed or inhaled TSCA listed... [Pg.1395]

Dimethylamino) ethyl 2-methyl-2-propenoate. See Dimethylaminoethyl methacrylate N-(2-Dimethylaminoethyl)-N,N, N -trimethyl-ethane-1,2-diamine. See N,N, N",N"-Pentamethyldiethylenetriamine 2-Di methylam i no-4-hyd roxy-5-n-butyl-6-methylpyrimidine 2-Dimethylamino-4-methyl-6-n-butyl-6-hydroxypyrimidine. See 5-Butyl-2-dimethylamino-6-methylpyrimidin-4-ol 7-Dimethylamino-4-methylcoumarin CAS 87-01-4 Classification Lactone Empirical C12H13NO2 Properties M.w. 203.26 m.p. 144-146 C Toxicology LD50 (oral, mouse) 3890 mg/kg LDLo (oral, rat) 1500 mg/kg mod. toxic by ing. irritant TSCA listed... [Pg.1397]

Methyl-2-propenoic acid, 2-(dimethylamino) ethyl ester, homopolymer. See Polydimethylaminoethyl methacrylate 2-Methyl-2-propenoic acid, ethyl ester. See Ethyl methacrylate... [Pg.2680]

Synonyms 2-Propenoic acid, 2-methyl-2-(dimethylamino) ethyl ester, polymer and 1-ethenyl-2-pyrrolidinone, compd. with diethyl sulfate Quaternium-23 Vinylpyrrolidone/dimethylaminoethyl methacrylate copolymer/diethyl sulfate reaction product... [Pg.3558]

Propenoic acid, 2-methyl-2-(dimethylamino) ethyl ester, polymer and 1-ethenyl-2-pyrrolidinone, compd. with diethyl sulfate. See Polyquaternium-11 2-Propenoic acid, 2-methyl, 2-[(1,1-dimethylethyl) amino] ethyl ester. Seet-Butylaminoethyl methacrylate 2-Propenoic acid, 2-methyl-, 1,1-dimethylethyl ester. See t-Butyl methacrylate Propenoic acid methyl ester 2-Propenoic acid methyl ester. See Methyl acrylate 2-Propenoic acid, methyl ester, homopolymer. See Polymethyl acrylate 2-Propenoic acid, 2-methyl-, 1,2-ethanediylbis (oxy-2,1-ethanediyl) ester. See PEG-3 dimethacrylate... [Pg.3723]

Synonyms Poly (1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate) 2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, polymer with 1-ethenyl-2-pyrrolidinone Vinylpyrrolidone/dimethylaminoethyl methacrylate copolymer Definition Polymer from vinylpyrrolidone and dimethylaminoethylmethacrylate monomers Toxicology Irritant... [Pg.3782]

The microwave-assisted [2+2] cycloaddition reactions of 2-amino-3-dimethylami-no propenoates with acetylenecaiboxylates lead to produce highly functionalized l-amino-4-(dimethylamino) buta-1,3-dienes in high yield (Ursic et al., 2008). It has also been observed that single geometrical isomers were produced consistently in all these reactions. [Pg.132]

Thoron II, T-00178 2-(Benzoylamino)-3-[4-(dimethylamino)phenyl]-2-propenoic acid, B-00120 //-Resorcine, R-OOOOl Beryllon III, in A-00211 Chlorophosphonazo R, C-00245 Chlorotrihexylsilane, C-00266 Ethyl... [Pg.1177]

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