2.6- dimethyl-3,5-dioxo-4-ethyl

Dichloro-2,6-dimethyl-3,5-dioxo-4-ethyl- E12b, 536 (R-CH2-CO-A-CO-CH2-R + TeCl4)... [Pg.646]

Azetidin l,4-Dimethyl-4-ethyl-3-methoxycarbonyl-2-oxo- E16b, 538 (aus 3-Diazo-2,4-dioxo-pyrrolidin)... [Pg.657]

Using an oxalic ester replaces a reactive hydrogen atom by an oxo ester (alkoxalyl) group.750 Thus diethyl 3-methyl-2-oxoglutarate is obtained in 70% yield from ethyl propionate and diethyl oxalate 751 and dimethyl dioxo-homonorcamphorate [methyl(3-methoxycarbonyl-2-oxocyclopentyl)glyoxalate] can be prepared in 90% yield from ethyl 2-oxocyclopentanecarboxylate and methyl oxalate 752... [Pg.962]

Chemical Name N-[(cyclohexylamino)carbonyl] -4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1 H)-isoquinolinyl)ethyl] benzenesulfonamide... [Pg.731]

Saalfrank, Hoffmann and co-workers performed a number of reactions with tetra-alkoxyallenes such as 196 (Scheme 8.47) [1, 41, 105, 114—116] and demonstrated that this class of donor-substituted allenes can serve as a 1,3-dianion equivalent of malonic acid. Treatment of 196 with cyclopropyldicarboxylic acid dichloride 197 produces 2,4-dioxo-3,4-dihydro-2H-pyran 198 through release of two molecules of ethyl chloride [115]. Similarily, the reaction of this allene 196 with oxalyl chloride gives 3-chloromalonic acid anhydride derivative 199. This intermediate is a reactive dieno-phile which accepts 2,3-dimethyl-l,3-butadiene in a subsequent [4+2] cycloaddition to afford cycloadduct 200 in good yield [116]. [Pg.458]

Piperacillin Piperacillin, (25,5/ ,6/ )-3,3-dimethyl-7-oxo-6-[(2R)-2-[(4-ethyl-2,3-dioxo-l-piperazinyl)formamido]-2-phenylacetamido]-4-thia-l-azabicyclo[3.2.0]-heptan-2-car-boxylic acid (32.1.1.30), is also synthesized by acylating ampiciUin (32.1.1.16), but with l-chlorocarbonyl-4-ethylpiperazin-2,3-dione (32.1.1.29). The necessary l-chlorocarbonyl-4-ethylpiperazin-2,3-dione (32.1.1.29) is synthesized by reacting M-ethylethylenediamine with diethyloxalate, forming 4-ethylpiperazin-2,3-dione (32.1.1.28), and then acylating this with phosgene after initial silylation of the product at the nitrogen atom with trimethylchlorosi-lane [47-50]. [Pg.439]

PROPIONIC ACID, 2-(4-CHLOROPHENOXY)-2-METHYL-, 2-(1.2,3,6-TETRAHYDR0-l,3-DIMETHYL-2,6-DIOXO-7H-PURIN-7-YL) ETHYL ESTER... [Pg.235]

Ethyl 4,8-dimethoxy-l,5-naphthyridine-3-carboxylate (28, R = C02Et) underwent thermal rearrangement to ethyl 1,5-dimethyl-4,8-dioxo-1,4,5,8-tetrahy-dro-l,5-naphthyridine-3-carboxylate (29, R = C02Et) (Ph20, reflux, 6.5 h 5% after a difficult separation from other products) 301 somewhat similarly, 4,8-dimethoxy-l,5-naphthyridine (28, R = H) gave 1,5-naphthyridine-4,8(lff,5fl)-dione (29, R = H) (neat substrate, 225°C, 10 h 62%).301... [Pg.49]

Benzoyl-iV-ethyl-1 -methylthiovinylamine (4) with 2-cyano-A -methylaceta-mide (2 mol) gave l-amino-2,7-dimethyl-3,8-dioxo-6-phenyl-2,3,7,8-tetrahy-dro-2,7-naphthyridine-4-carbonitrile (5) (reactants, Pr ONa, Pr OH, reflux 75% analogs likewise).699... [Pg.276]

Ethyl 2-chloro-1,5-naphthyridine-3-carboxylate Ethyl 4-chloro-1,5-naphthyridin-3-carboxylate Ethyl 6-chloro-4-oxo-1,4-dihydro-1, 5-naphthyridine-3-carboxylate Ethyl 7-chloro-4-oxo- 1,4-dihydro-1, 5-naphthyridine-3-carboxylate Ethyl l,5-dimethyl-4,8-dioxo-l,4,5,... [Pg.343]

Ethyl 1,6-dimethyl-3,8-dioxo-7-phenyl-2,3,7,8-tetrahydro-2,7-naphthyridine-4-carboxylate Ethyl l-oxo-l,2-dihydro-2,7-naphthyridine-3-carboxylate... [Pg.412]

Reaction of 9-fluoro-8-isothiocyanato- and 8-iso(thio)cyanato-3,5, 6,7-tetrahydro-2//-pyrido[l,2,3-de]-l,4-benzoxazines with 2-amino-4,4-dimethylpyrroline, then with Br2, and with ethyl pipecolinate yielded 8-(6, 6-dimethyl-3,5,7,7-tetrahydropyrrolo[2,l-c][l,2,4]thiadiazol-3-ylidenamino)-9-fluoro and 8-(l,3-dioxo and l-oxo-3-thioxoperhydroimidazo[l,5-a]-pyridin-2-yl) derivatives, respectively (89EUP406993). Treatment of 9-fluoro-8-(2-hydroxymethylpiperidinothiocarbonylamino)-3,5,6,7-tetrahydro-2//-pyrido[l,2,3-de]-l,4-benzoxazine with HC1 gas in EtOH gave the 8-(perhy-dropyrrolo[l,2-c]thiazol-3-ylidenamino) derivative. [Pg.177]

C H27N04 109554-69-0) see Mebeverine (4/f,5K)-2-ethyl-2-(6-methoxy-2-naphthalenyl)-l,3-dioxo-lane-4,5-dicarboxylic acid dimethyl ester... [Pg.2382]

Dioxo-3-ethyl- XIII/2a, 794 f. Pentanal 2,3-Dimethyl-4-oxo- EI9a,... [Pg.407]

Dioxan 2,2-Dimethyl-4,6-dioxo-5-ethyl- E14a/1, 717 (Keton + HOOC-CHR-COOH)... [Pg.516]

Aza-bicyclo[3.2.1 oct-2-en 2-Carboxy-8-methyl- V/Id, 394 Bicyclo[2.2.1 hepten 5,6-Dimethyl-5-nitro- X/l, 397f. 5-Ethyl-5-nitro- X/l, 397f. Cyclobuten 2-Diethylamino-3,4-dioxo-1-methyl-E15/2. 1427 (F/Cl -> Oxo)... [Pg.640]

H-Purin 3,7-Dimethyl-2,6-dioxo-8-[l-(2-hydroxy-ethyl)-hydrazino]-... [Pg.649]

H-Purin 7-(2-Amino-ethyl)-1,3-dimethyl-2,6-dioxo-8-hydrazino-1,2,3,4-tetrahydro- E16a, 684 (Br -> NH-NH2)... [Pg.659]

Pnrin 8-(Bis-[2-hydroxy-ethyl]-triazeno)-l,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro- X/3, 705... [Pg.922]

PHOSPHORODITHIOIC ACID, S-(6-CHLORO-3,4-DIHYDRO-2H-1-BENZOTHIOPYRAN-4-YL) 0,0-DIMETHYL ESTER see CLH820 PHOSPHORODITHIOIC ACID-S-(2-CHLORO-l-(l,3-DIHYDRO-l,3-DIOXO-2H-ISOINDOL-2-YL))ETHYL-0,0-DIETHYL ESTER see DBI099 PHOSPHORODITHIOIC ACID-S-((2-CHLORO-l-PHTHALIMIDOETHYL)-0,)-DIETHYL ESTER see DBI099... [Pg.1841]

Dimethyl-2,6-dioxo-l,2,3,6-tetrahydro-7/f-purin-l-yl)ethyl Methacrylate (13) Typical Procedure ... [Pg.454]

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