3.4- Dimethyl-2,6-dinitro

Azetidin 3-Azido-l-(ethoxycarbonyl-methyl)-4-(2-furyl)-2-oxo- E16b, 372 (N3-C-CO-CI + Imin) Benzimidazol 5,6-Dimethyl-4,7-dinitro-1-ethyl- E8c, 330 [4.7-H2 - 4,7-(N02)2[... 

N,N-Dimethyl-dinitro-toluidines 5 D1375-D1376 13-Dimethyl-1, 3-dinitrourea 5 D1378 Dimethyldiphenyl see Bitolyl and derivs 2 B163... 

I itro-DisplacementPolymerization. The facile nucleophilic displacement of a nitro group on a phthalimide by an oxyanion has been used to prepare polyetherimides by heating bisphenoxides with bisnitrophthalimides (91). For example with 4,4 -dinitro monomers, a polymer with the Ultem backbone is prepared as follows (92). Because of the high reactivity of the nitro phthalimides, the polymerkation can be carried out at temperatures below 75°C. Relative reactivities are nitro compounds over halogens, Ai-aryl imides over A/-alkyl imides, and 3-substituents over 4-substituents. Solvents are usually dipolar aprotic Hquids such as dimethyl sulfoxide, and sometimes an aromatic Hquid is used, in addition. 

Nitration of a series of methyl-1,2-benzisoxazoles was studied by Tahkar and Bhawal using fuming nitric acid and sulfuric acid in acetic acid at 100 °C. 3-Methyl-1,2-benzisoxazole gave a mixture of 5-nitro- and 5,7-dinitro-3-methyl-l,2-benzisoxazole, with the 5-nitro isomer predominant. The product obtained from 3,5-dimethyl-1,2-benzisoxazole was the 4-nitro derivative and not the 7-nitro compound as proposed by Lindemann (26LA(449)63). The synthesis of the 7-nitro compound by an alternative method was used as structural proof. Two products were obtained from 3,6-dimethyl-l,2-benzisoxazole and these were the 5-nitro and 5,7-dinitro derivatives. 3,7-Dimethyl-l,2-benzisoxazole was converted into the 5-nitro derivative (Scheme 25) (77lJC(B)l06l). 

Furan, 3-(4,8-dimethyl-3,7-nonadienyl) — see Dendrolasin Furan, 2,5-dinitro-synthesis, 4, 711 Furan, 2,5-diphenyl-bischloromethylation, 4, 607 Furan, 3-ethoxycarbonyl-2,5-dimethyl-synthesis, 4, 659 Furan, 2-ethyltetrahydro-synthesis, 3, 776, 4, 711 Furan, fluoro- F NMR, 4, 564 H NMR, 4, 564 Furan, halo-... 

Isoxazole, 3,5-dimethyl-3,4-dinitro-quatemization, 6, 21 Isoxazole, 3,5-dimethyl-4-nitro-basicity, 6, 20 reactions, 6, 50... 

Thiophene, 2,5-dimethyl-3-lithio-ring opening, 4, 81 Thiophene, 2,5-dimethylthio-3,4-disubstituted synthesis, 4, 872 Thiophene, dinitro-... 

Dimethyl sulfate, 57 Dimethyl sulfide, 57 Dimethyl sulfoxide, 57 Dimethyl terephthalate, 57 Dimetilan, 57 Dinitroanilines, 57 Dinitrobenzenes, 58 Dinitrolmide, 58 Dinitronaphthalenes, 58 Dinitro-o-Cresol, 58 Dinitrophenols, 58... 

Quinoxalin-2-one is a very weak base (pK — 1.37) and so the different orientation of substitution in acetic and sulfuric acids may mean that in acetic acid the principal species undergoing nitration is the neutral molecule, and in sulfuric acid, the mono-cation. Treatment of quinoxaline-2,3-dione, or its iViV -dimethyl derivative in sulfuric acid, with 1 equivalent of potassium nitrate, results in nitration at position 6 with 2 equivalents of potassium nitrate, 6,7-dinitro compounds are formed. When quinoxaline is boiled with aqueous nitric acid, 6-... 

It has already been mentioned that 5-methylisoxazole is converted into a pyrazole derivative by phenylhydrazine. All 4-nitroisoxazoles undergo this same reaction (136— 137)/° 5,5 -Dimethyl-4,4 -dinitro-3,3 -diisoxazolyI reacts similarly... 

Dinitro-5-methoxy-naphthol-(l), methyl-[6,8-Dinitro-5-hydroxy-naphthyl-(])] -ether). (O2N)2C10H4(0H).O.CH3, mw 264.21, N 10.61%, OB to C02 —121.12%, orange needles from CCI4, mp 173° (decompn). Sol in CCI4. Prepn from 2,4-dinitro-naphthalenediol-(l,5) by reacting with an excess of dimethyl sulfate in dil NaOH... 

Dimethyl-2,2,4,4-tetranitropentane 2,3-Dimethyl-3,4-dinitro-2,3-bis (nttromethyl) butane 2,5-Dimethyl-2,33,4,4,5-hexanitro-hexane 3,4-Dimethyl-2,2,3,4,5,5-hexanitro-hexane and 2,2,4,4-Tetrakis (nitromethyl) pentane. Ref 2 details a listing of a variety of methods attempted in these unsuccessful syntheses... 

Dinitro-2,2-Dimethyl propane. See under 2,2 -Dime thyl-1,3 -dinitropropane or Dinitroneo-propane in Vol 5, D1368-R... 

Dinitro-benzol kann in 20%iger Sehwefelsaure bei 70-90° quantitativ zu 1,3-Di-amino-benzol reduziert werden (Stromausbeute 96,5%)s. Ebenfalls auf industrieller Basis wird aus 2,4-Dinitro-toluol2,4-Z5mmmo-io/uo/ (Pb, —0,9 V, 50°, in Gegenwart von 1,4-Dimethyl-benzolsulfonsaure 71% d.Th.) hergestellt6. 

Dihydroxy- -oxim 699 4,4 -Dimethoxy- -O-methyl-oxim 377 4-(2,3-Dimethyl-butyl-(2)]- 565 2,2 -Dinitro- 474, 558 4,4 -Diphenyl- 542 2 -Fluor-4-chlor- 288... 

Acetyl-phenyl- 635 4-Amino-3,5-dimethyl-phenyl- 102 2-Amino-4-hydroxy-phenyl- 692 4-Amino-phenyl- 685 4-Benzylamino-phenyl- 102 2,4-Dinitro-phenyl- 692 4-(2-Hydroxy-benzylamino)-phenyl- 102 2-(2-Methyl-butanoyl)-phenyl- 635 4-Methoxy-2,6-dimethyl-phenyl-102 (Nitro-phenyl)- 635 2-Nitro-phenyl- 680, 692 4-Nitro-phenyl- 685... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

Recent examples of this synthesis are of two types. The first involves condensation of the activated phenol, 2-amino-4,6-dinitrophenol (346a) with 2-dimethyl-amino-3,3-dimethyl-3//-azirine (346b) (in MeCN, 0°C- 20°C, A, 24 h) to afford a separable mixture of four products, one of which was 2-dimethylamino-3,3-dimethyl-5,7-dinitro-3,4-dihydroquinoxaline (346c) ( 20% yield) and another its hydrolysis product, 3,3-dimethyl-5,7-dinitro-3,4-dihydro-2(l//)-quinoxalinone (346d) ( 8%) the mechanism of such condensations has been discussed. ... 

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