Dimethyl-carbamic acid ethyl ester

CARBAMIC ACID, (((((l,4-DITHIAN-2-YLIDENEAMINO)OXY)CARBONYL)METHYLAMINO )THIO)METHYL-,ETHYL ESTER see MLLIOO CARBAMC ACID, ESTER WITH SALICYLALDEHYDE DIMETHYL ACETAL see SAGIOO CARBAMIC ACID, ETHYLENEBIS(DITHIO)-, MANGANESE SALT see MAS500 CARBAMIC ACID, ETHYL ESTER see UVAOOO CARBAMIC ACID, ((4-... 

C22HmNj05 171504-92-0) see Indinavir sulfate [3S-[2(lS, 2S ),3a,4aP,8aPIH3-I3- (l,l-dimethyl-ethyl)amino carbonyl)octahydro-2(l//)-isoquinolinyl -2-hydroxy-l-((phcnylthio)mcthyl propyl carbamic acid phenylmethyl ester... 

Carbamic acid, (aminoiminomethyl)methyl-, dimethyl deriv., ethyl ester, monohydrochloride. 

Carbamic acid, (aminoiminomethyl)methyl-, dimethyl deriv., ethyl ester, monohydrochloride EiNECS 265-620-8 Ethyl (dimethylamidino)methyicarbamate, hydro-chloride Ethyl amidinomethylcarbamate monohydro-chloride, dimethyi derivative. 

N-tert-Butoxycarbonyl-L-leuc1ne N-methy1-0-methy1carboxamide Carbamic acid, [l-[(ii)ethoxymethylamino)carbonyl]-3-methylbutyl3-, 1,1-dimethyl ethyl ester... 

Carbamic acid nitrile. See Dimethyl cyanamide Carbamic acid, 1-phenylethyl-, ethyl ester. See trans-1,4-Dimethylcyclohexane Carbamide. See Urea Carbamide peroxide. See Urea peroxide Carbamide resin Carbamidic acid. See Urea... 

Synonyms Carbamic acid, 1-phenylethyl-, ethyl ester Cyclohexane, 1,4-dimethyl-, trans-... 

Atazanavir enzymatic preparation of (1 /9-[3-chloit>-2-hydroxy-1-(phenylinethyl) propylj-carbamic acid,1,1-dimethyl-ethyl ester. 

CHLORO-2-HYDROXY-1 (PHENYLMETHYL) PROPYLJ-CARBAMIC ACID, 1,1-DIMETHYL-ETHYL ESTER... 

Alkyl esters are efficiently dealkylated to trimethylsilyl esters with high concentrations of iodotrimethylsilane either in chloroform or sulfolane solutions at 25-80° or without solvent at 100-110°.Hydrolysis of the trimethylsilyl esters serves to release the carboxylic acid. Amines may be recovered from O-methyl, O-ethyl, and O-benzyl carbamates after reaction with iodotrimethylsilane in chloroform or sulfolane at 50—60° and subsequent methanolysis. The conversion of dimethyl, diethyl, and ethylene acetals and ketals to the parent aldehydes and ketones under aprotic conditions has been accomplished with this reagent. The reactions of alcohols (or the corresponding trimethylsilyl ethers) and aldehydes with iodotrimethylsilane give alkyl iodides and a-iodosilyl ethers,respectively. lodomethyl methyl ether is obtained from cleavage of dimethoxymethane with iodotrimethylsilane. 

Cyclopropanols can be converted to various cyclopropyloxy derivatives (esters, e.g. acetates, ethers, e.g. methyl and ethyl ethers, and acetals, e.g. tetrahydropyran-2-yloxy derivatives) under the appropriate reaction conditions. In most cases the synthesis of cyclopropyl esters by the reaction between a cyclopropanol and an acid chloride (e.g. formation of 1 ) or acetic anhydride (e.g. formation of 2 ) have been reported. The yields were particularly good (84-95%) when acetic anhydride was used, although a drawback of the reaction can be byproduct formation. When a reactive moiety is attached to the cyclopropane ring in addition to the hydroxy group, other reactions can also occur m-l-(aminomethyl)-2,2-dimethyl-3-(2-methylprop-l-enyl)cyclopropanol (3) reacted with phosgene in benzene to give the corresponding carbamate l,l-dimethyl-2-(2-methylprop-l-enyl)-4-oxa-6-azaspiro[2.4]heptan-5-one (4) in 31% yield. ... 

Amino-l-hydroxyethyl)phosphonic acid occurs in the plasma membrane of Acanthamoeba castellani and the 2R isomer is formed, in that organism, by the hydroxy-lation of (2-aminoethvl)phosphonic acid This biosynthesis step in vitro has been studied by Hammerschmidt" who synthesized various chiral deuterium-labelled derivatives of both compounds using the isotopically labelled 2-benzyloxyethanal in Abramov reactions to obtain, initially, the dimethyl (2-benzyloxy-l-hydroxyethyl)phosphonate (362). This ester was resolved through the diastereoisomeric carbamates 363 the separated carbamates were sequentially de-l-O-protected, silylated at the a-HO group, debenzylat-ed and, by means of the Mitsunobu reaction, converted into dimethyl [2-eizido- -(tert-butyldimethylsilyloxy)ethyl]phosphonates. Subsequently, standard reactions were used to transform the latter into the diastereoisomeric, isotopically labelled (2-amino-1-hydroxy-ethyl)phosphonic acid. 

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