3- propyl carbamate

NHjCOOCHj) Ethyl carbamate (urethane) n-Propyl carbamate. n-Butyl carbamnte n-Amyl carbamate t o-Amyl carbamate. N-Methylurethane... 

A mixture of 24.1 g (0.10 mol) of 3-o-methoxyphenoxy-2-hydroxy-1 -propyl carbamate and 6.0 g (0.10 mol) of urea was heated rapidly to the temperature range of 180°C to 200°C, and maintained there for five hours. The reaction melt was poured into 50% ethyl alcohol, from which the product crystallized as a white solid. The crude yield was 18.3 g (82%) melting point 131.5°C to 137 t. Crystallization from water and 95% alcohol gave 9.0 g (40.3%) of pure 5-o-methoxyphenoxymethyl-2-oxazolidone melting point 141°Cto 143. This melting point was not depressed when the material was mixed with an authentic sample. In additional runs acetone was used Instead of ethyl alcohol with equivalent results. 

Diethylmethyl propylmalonate is reacted with LiAIH4, then H2SO4 to give 2-methyl-2-propyl-1,3-propanediol. That is reacted with phosgene in toluene to give the chlorocar-bonate which is in turn reacted with butylamine to give N-butyl-2-methyl-2-propyl-3-hy-droxy-propyl carbamate. 

CN [(lS,2/ )-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-l-(phenylmethyl)propyl]carbamic acid (3S)-tetrahydro-3-furanyl ester... 

C7H,5N04 86780-81-6) see Aranidipine (4-aminobutyl)[3-[[(l,l-dimethylethoxy)carbonyl]amino]-propyl]carbamic acid 1,1-dimethylethyl ester... 

D(-)-2-(4-hydroxyphenyl)glycyl chloride hydrochloride see under D-/ -hydroxyphenylglycyl chloride hydrochloride 7-hydroxy-7-phenylheptanoic acid (CijHigOi 103187-18-4) see Seratrodast [/ -(/J, S )]-[2-hydroxy-l-[[(phenylmethoxy)amino]carbo-nyl]propyl]carbamic acid l,l carbonyl]amino]hep-tanoic acid... 

C22HmNj05 171504-92-0) see Indinavir sulfate [3S-[2(lS, 2S ),3a,4aP,8aPIH3-I3- (l,l-dimethyl-ethyl)amino carbonyl)octahydro-2(l//)-isoquinolinyl -2-hydroxy-l-((phcnylthio)mcthyl propyl carbamic acid phenylmethyl ester... 

No reference to the preparation of w-butyl carbamate is to be found in the literature. The above process is adapted from that of Cahours,1 who prepared -propyl carbamate by heating propyl alcohol with urea. w-Butyl carbamate has also been prepared by one of the editors by the action of w-butyl chloro-formate upon ammonia. 

Preparation of ( )- 3-[l-(5-benzyl-3-methyl-4-Oxo-4,5-dihydro-isoxazolo-[5,4-d]pyrimidin-6-yl)-propylamino]-propyl -carbamic acid t-butyl ester... 

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