Dimethindene

Dimethindene maleate -Dimethylaminoethyl mercaptan HCI Echothiopate iodide Dimethylaminoisopropyl chloride Isothipendyl HCI 3,4-Dimethyl-6-amino isoxazole Sulfisoxazole... 

Fontego - Bumetanide Fonzylane - Buflomedil Forane Isoflurane Fordex - Tolbutamide Fordiuran Bumetanide Foreart Inosine Forenol -Niflumic acid Forhistal Dimethindene maleata Foristal - Dimethindene maleate Formaftil - Formocortal acetate Formulex Dicyclomine HCI Fortabol -Methenolona acetate Fortabolin - Nandrolone decanoate Fortapen - Ampicillin Fortasec - Loperamide HCI Fortecortin Dexamethasone acetate Fortesul Sulfameter... 

Antagonists. Most of the so-called Hi-antihistamines also block other receptors, including M-cholinoceptors and D-receptors. Hi-antihistamines are used for the symptomatic relief of allergies (e.g., bamipine, chlorpheniramine, clemastine, dimethindene, mebhydroline pheniramine) as antiemetics (meclizine, dimenhydrinate, p. 330), as over-the-counter hypnotics (e.g., diphenhydramine, p. 222). Promethazine represents the transition to the neuroleptic phenothiazines (p. 236). Unwanted effects of most Hi-antihistamines are lassitude (impaired driving skills) and atropine-like reactions (e.g., dry mouth, constipation). At the usual therapeutic doses, astemizole, cetrizine, fexofenadine, and loratidine are practically devoid of sedative and anticholinergic effects. Hj-antihistamines (cimetidine, ranitidine, famotidine, nizatidine) inhibit gastric acid secretion, and thus are useful in the treatment of peptic ulcers. 

B Chankvetadze, G Pintore, N Burjanadze, D Bergenthal, K Bergander, J Breitkreutz, C Muhlenbrock, G Blaschke. Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native /3-CD and heptakis-(2,3,6-tri-0-methyl)-/3-CD. J Chromatogr A 875 455-469, 2000. 

Two brief examples are presented to illustrate structure-activity problems for which this approach might be useful. The first example (Fig. 16) finds the similar structural features among five structurally diverse antihistamines (diphenhydramine, methapyrilene, cyproheptadine, dimethindene and promethazine). 

Fig. 16. Similar structural feature among five antihistamines (diphenhydramine, methapyrilene, cyproheptadine, dimethindene and promethazine)...

Dimethindene Bulk HPLC Silica Methylene chloride- 254 nm TLC [1] GC [2,10] [10]... 

Carbinoxamine, dimethindene, doxyl-amine, iproniazid, phenyramidol, triprol-idine (1-2 min)... 

Acepromazine (- red), adiphenine (-> blue), benorylate, bephenium hydroxynaphthoate, bibenzonium, buclosamide (blue rim), bunamidine, chlorpromazine (-> violet), clefamide (— brown), codeine, colchicine, cyclazocine, cyclomethycaine (— brown), debrisoquine, diaveridine, dibenzepin, diethazine (— violet with excess reagent), diethylthiambutene (-> green-blue), dimethindene, dimethoxanate (— brown), dimoxyline, dipipanone (— blue), dothiepin, doxorubicin, doxycycline (-> yellow), ethopropazine violet), fenpiprane,... 

Quinine Ethyl Carbonate 408.5 Dimethindene Maleate 424.3 Dibenzepin Hydrochloride... 

Procaine Hydrochloride 161d Dimethindene Maleate Protriptyline Hydrochloride... 

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