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Diluents spray dried

Protein-based drugs have been formulated mainly as stable liquids or in cases where liquid stability is limiting as lyophilized dosage forms to be reconstituted with a suitable diluent prior to injection. This is because their delivery has been limited primarily to the parenteral routes of intravenous (IV), subcutaneous (SC), or intramuscular (IM) administration. There are a few drugs that have been developed for pulmonary delivery, such as rhDNase (Pulmozyme ) and an inhalable formulation of insulin (e.g., Exubra ). However, even such drugs have been formulated as either liquid or lyophilized or spray-dried powders. This chapter will focus only on excipients that are applicable to liquid and lyophilized protein formulations. [Pg.292]

The first direct compression excipient, spray-dried lactose, was introduced in the early 1960s as a filler specifically designed for direct compression processes. Over many years, more direct compression API and excipients, especially diluents and binders, were developed. Since these are now commercially available, design of direct compression formulations is readily possible. However, despite the simplicity of the direct compression process, the pharmaceutical industry still produces most tablets by wet granulation methods.1... [Pg.159]

Spray-dried lactose, starch, Diluent or Bulk density, tapped density,... [Pg.233]

Sodium Chloride. Sodium chloride (NaCl) is used by some detergent manufacturers, its main function being as an inert filler or diluent. In spray-drying operations, NaCl is used to control Crutcher slurry viscosity and the density of the spray-dried bead or granules. In liquid formulations, NaCl is used to control product viscosity through the salt effect. Although salt is used to some extent in autodish formulations, it is not recommended because of potential machine and dishware corrosion. [Pg.1733]

Details of some direct compression diluents are given in Table 6. The majority of these are available from only one supplier, though the two most frequently used—spray-dried lactose and microcrystalline cellulose—are available from several sources. [Pg.3662]

At about the same time, two materials were introduced that were specifically designed to act as tablet diluents and would not require preliminary treatment. These were spray-dried lactose and microcrystalline cellulose, introduced in 1962 and 1964, respectively. These two substances can be said to have initiated the direct compression revolution. Since that time, a wide range of direct compression tablet diluents has become available. The properties of some of these materials will be reviewed later in this article. [Pg.3673]

A faulty batch of tablets can sometimes be recovered by grinding up the tablets and recompressing them, a process which is known as reworking and is analogous to the dry granulation method of tablet manufacture. This can sometimes cause problems with a direct compression formulation. Many direct compression diluent particles are in the form of aggregates, e.g., spray-dried lactose is composed of small crystals of lactose embedded in amorphous lactose. If these aggregates are compressed, their structure may be broken down to such an extent that subsequent recompression will result in impaired tablet quality. [Pg.3677]

Sorbitol can exist in four crystalline forms. Guyot-Hermann, Leblanc, and Draguet-Brugmans compared 11 commercially available varieties of sorbitol, and found three of these four forms to be present. y-Sorbitol was found to be the most useful as a tablet diluent. The method of manufacture has also been shown to affect tabletting properties, differences being attributed to variations in particle shape and surface properties. Spray-dried varieties of sorbitol are available as direct compression diluents which are claimed to have overcome problems associated with the different crystalline forms. ... [Pg.3681]

Though numerous direct compression diluents are available, none is ideal. For example, spray-dried lactose flows easily but forms relatively weak tablets. [Pg.3682]

Armstrong, N.A. Lowndes, D.H.L. The use of mixtures of spray-dried lactose and microcrystalline cellulose as direct compression diluents. Int. J. Pharm. Tech, and Prod. Manuf. 1984, 5 (3), 11-14. [Pg.3683]

Uses Absorbent, binder, emulsion stabilizer, film-former in cosmetics, bath prods. nutritive polymer, carrier, bulking agent, absorbent in foods, pharmaceuticals carrier for fragrances and flavors coating and spray drying aid tablet/capsule diluent, coating agent, binder, vise, builder Features Nonsweet... [Pg.1182]

Modified zeolites for use in an industrial reactor should have the right physical form and shape implied by the choice of the reactor (Chapter 9). FCC in a fluid-bed reactor requires spherical particles (70-100 [im), obtained by spray drying of the [im-sized USY zeolite crystals in the presence of a binder, viz. silica, alumina, and clays [21]. Extrusion requires a binding agent that attributes to the zeolite/binder mixture tixotropic properties in the extruder [22]. As the catalyst binder may be active, it exceeds the role of diluent agent for the active zeolite [21]. Indeed, the steam stability of some zeolites is known to be enhanced in a binder[Pg.244]

Figure 8 Typical layout of the closed-cycle spray dryer system c, coolant (diluent) f, feed 1, solvent recovery p, spray-dried product. 1, dried powder 2, cyclone 3, liquid-phase indirect heater 4, heat exchanger 5, scrubber-condenser. (Adapted from Ref. 11.)... Figure 8 Typical layout of the closed-cycle spray dryer system c, coolant (diluent) f, feed 1, solvent recovery p, spray-dried product. 1, dried powder 2, cyclone 3, liquid-phase indirect heater 4, heat exchanger 5, scrubber-condenser. (Adapted from Ref. 11.)...
Spray-dried lactose By spray drying a suspension of a-lactose monohydrate Binder, Diluent... [Pg.5]

Crude ficin (latex) is cream to pinkish in color and has an acidic pH (usually 3-4). It is usually purified by filtration, followed by spray-drying. Commercial purified ficin is not pure ficin but is a mixture of several proteases and small amounts of other enzymes (e.g., peroxidases) in addition to diluents (e.g., lactose, dextrose, or starch) and other constituents. ... [Pg.292]


See other pages where Diluents spray dried is mentioned: [Pg.1875]    [Pg.299]    [Pg.313]    [Pg.1634]    [Pg.278]    [Pg.3670]    [Pg.3675]    [Pg.3681]    [Pg.260]    [Pg.2316]    [Pg.2299]    [Pg.1879]    [Pg.74]    [Pg.506]    [Pg.154]    [Pg.155]    [Pg.161]    [Pg.68]    [Pg.7]    [Pg.540]    [Pg.712]    [Pg.278]    [Pg.386]    [Pg.326]    [Pg.901]    [Pg.2202]    [Pg.366]    [Pg.152]    [Pg.299]   
See also in sourсe #XX -- [ Pg.396 ]




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