Diluents calcium sulfate

The polysulfide base material contains 50—80% of the polyfunctional mercaptan, which is a clear, amber, sympy Hquid polymer with a viscosity at 25°C of 35, 000 Pa-s(= cP), an average mol wt of 4000, a pH range of 6—8, and a ntild, characteristic mercaptan odor. Fillers are added to extend, reinforce, harden, and color the base. They may iaclude siUca, calcium sulfate, ziac oxide, ziac sulfide [1314-98-3] alumina, titanium dioxide [13463-67-7] and calcium carbonate. The high shear strength of the Hquid polymer makes the compositions difficult to mix. The addition of limited amounts of diluents improves the mix without reduciag the set-mbber characteristics unduly, eg, dibutyl phthalate [84-74-2], tricresyl phosphate [1330-78-5], and tributyl citrate [77-94-1]. 

Terra alba or dead-burned, fine white gypsum is used as a paper filler, in plastics, and as an exlender far titanium dioxide. Pharmaceutically pure gypsum can be added to bread and other bakery products, finds use in beer production, and as a pharmaceutical-tablet diluent. In Japan, calcium sulfate is used in making tofu, a soyabean curd. 

Diluents. In general, diluents make up most of the dosage form. The selection of diluents is very important, especially for low-dose formulations, since they may make up 85-95% of the granulation. These diluents may be soluble or insoluble. The most commonly used soluble fillers include lactose, mannitol and sucrose. Commonly used insoluble fillers include microcrystalline cellulose, starch, calcium sulfate, and dibasic calcium phosphate. 

Calcium carbonate, calcium sulfate, kaolin, talc, magnesium carbonate, and zinc oxide are frequently used as nutrient supplements or food diluents. Calcium silicate and fumed silica are used as anticaking agents. They are added in concen-... 

This calcium sulfate can be removed by filtration, but generally it is left in the slurry where it may be considered as a diluent that supplies two secondary nutrients-, calcium and sulfur. 

The choice of a diluent may influence the absorption of an active substance, which was seen in the l%Os in Australia. The diluent of phenytoin sodium capsules was changed from calcium sulfate dihydrate to lactose, which strongly enhanced the bioavailabdity of phenytoin sodium. Plasma levels of phenytoin increased up to fourfold, which led to an increased reporting of adverse events [8,9]. This case drew worldwide attention and resulted in an increased awareness of the importance of pharmaceutical availability and bioavailability of active substances in the development of solid oral dosage forms. 

Calcium Sulfate Dihydrate has been suggested as a diluent for granulated tablet systems containing up to 30% of active ingredient. Also known as terra alba (gypsum), it is an inexpensive, nonhydroscopic powder. It is the least expensive tablet filler and can be used for a wide variety of acidic, neutral, and basic drugs. 

Additives used in final products Plasticizers/flexibilizers epoxidized oils, low molecular polyamides, polysulfidesdibutyl phthalate, condensation products of adipic acid and glycols, isodecyl pelargonate, cyclohexyl pyr-rolidone Other diluents (glycide ether), modifiers, rheological additives, flame retardants Antistatics alkyl dipolyoxyethylene ethyl ammonium ethyl sulfate, carbon black, carbon monofiber, graphite, quaternary ammonium compound, silver-coated basalt, tin oxide Release calcium carbonate, carnauba wax, ceramic microspheres, ethylene bis stearoformamide, montan wax, silicone oil Slip carbon fiber, PTFE, sorbitan tristearate ... 

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