Diloxanide furoate suspensions

Figure 9.14(a) Redispersibility data for diloxanide furoate suspensions in the presence of nonylphenylethoxylates after 1 year s storage, (b) Redispersibility data for drug suspension in the presence of nonylphenylethoxylates after 3 days storage. From Rawlins [32]. 

Das and Haider described a simultaneous spectrophotometrie method for the analysis of binary dosage form mixtures of diloxanide furoate with metronidazole or with tinidazole [19], Powdered tablets or suspension, equivalent to 50 mg of the drug substances, were dissolved in 50 mL of dimethylformamide with shaking. After 15 minutes, the solution was diluted to 100 mL with water and filtered. A 1 mL portion of the filtrate was diluted to 50 mL with water, and the absorbance of the resulting solution measured at 320 and 262 nm for metronidazole and diloxanide furoate simultaneously. Alternatively, readings were taken at 318 and 262 nm for the simultaneous determination of tinidazole and diloxanide furoate. Recoveries were reported to be quantitative. 

Sadana and Gaonkar described a simultaneous derivative spectroscopic method for the determination of diloxanide furoate and tinidazole in pharmaceutical dosage forms [26]. Drugs were powdered and dissolved in methanol, and the solution set aside for 30 minutes with frequent shaking. After filtration, the filtrate and washings were diluted with methanol. A suspension equivalent to 150 mg of diloxanide furoate was extracted with chloroform. The filtered extract was evaporated to dryness, and the... 

Diloxanide furoate was determined by Sane al. using a simple spectrophotometric method [28]. The drug was extracted from tablets with ethanol, or was filtered from a suspension and dissolved in ethanol. The resulting solution was mixed with 6% aqueous sodium hydroxide and Folin-Ciocalteu reagent, or with a 1% solution of sodium nitroprusside in aqueous 10% sodium hydroxide. The complexes formed had absorbance maxima at 650 run, or at 675 nm, respectively. 

Sadana and Gaonkar have simultaneously determined diloxanide furoate and tinidazole in pharmaceutical dosage form by gas liquid chromatography [37]. Powdered tablets or suspension formulations were dissolved in chloroform, the solution filtered, and then diluted to 25 mL with chloroform. The solution also contained metronidazole as an internal standard. A 600 nL aliquot was analyzed on a stainless steel column (1 m X 3.2 mm) containing 3% of OV-17 on Chlorosorb W-UP (100-120 mesh). The GC system was operated at 200°C, using nitrogen as the carrier gas (45 mL/min). Flame ionization detection was used to observe the analytes. 

The nonylphenyl ethoxylates have also been used by Kayes and Rawlins in their work with diloxanide furoate and polystyrene latex [32]. Adsorption isotherms show the well-established trend with a maximum adsorbed concentration of NPEg of around 2/tmolg" and of NPE35 of about 0.35 mol Their results on the redispersibility of diloxanide suspensions, shown in Fig. 9.14, reflect therefore not the extent of adsorption of the surfactant molecules but their hydrophilic properties. The profiles can be compared with the corresponding sedimentation values for naphthalene and sulphathiazole above. 

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See also in sourсe #XX -- [ , ]

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