DILI

Tlic diterpene was rea,dily prepared in a perlcctly pure condition, so that it was possible lo determine saiislactorily ils ocimposiliou and physical properties. This well-cryswlUsed body is thus one ol the verv lew mcmbrics ol this class ol plant suhsUnces which can be prepared Irom natural sources in a parlectly pure condiUon. The oil was obtained by steam distillation, and contained about 3 per cent, of the solid diterpene. 

The oil distilir l in Geiman 7 cw hjain. -i does not dili er from thr Java oil in any ri ipec . and ihc- same i true of that distilled lu ihi. Malay peDiasiilii. -liiraaicii od has Iweii [ound to liavo the following characlers —... 

A fascinating reaction takes place starting with 9c (R = PhCMe2) and lithium powder in THF as the solvent. From the primarily formed 1,2-dilithioethane derivative 10c cumyllithium 12 is split off and the 2,2-bis(trimethylsilyl)vinyllithium 11 quantitatively dimerizes to yield the deep red dili-thiobutene derivative 13 ... 

In 1976, Schleyer et al. (200) reported that ab initio calculations on 1,1-dili-thioethylene (137) both on the STO-3G and the 4-31G levels gave the result that both energy and C=C bond length are remarkably insensitive to the angle of... 

Table 3 lists PAEs containing Si, Fe, and B. Silole containing Si in the five-mem-bered ring [157] has a low transition energy because of its low LUMO level [158], and its homopolymers have been prepared [159, 160]. 2,5-Dili-thiosiloles, which can be prepared by the ring-closing reaction of diethynyl-silane, serve as starting materials for various 2,5-disubstituted siloles such as 2,5-dibromosiloles and 2,5-di(trialkylstannyl)siloles [161,162]. PAEs with the silole ring have been reported as shown in Nos. 1-4 in Table 3. PAE-type polymers with Si atoms in the main chain have also been prepared (Nos. 12-16), and their optical properties including photoconductivity have been revealed [155,156].

Oxidative stress has increasingly been recognized as a key mechanism of DILI [83,... 

Drug DILI label Nuclei count (<0.4 = positive) Nuclei area (<0.4 = positive) ROS intensity (>2.5 = positive) TMRM intensity (<0.4 = positive) Lipid intensity (>2.5 = positive) GSH content (<0.4 = positive) GSH area (<0.65 = positive) GSH average pixel intensity (<0.4 = positive) HH imaging final score (logical OR of 8 measures) Human C ax (Pg/ml)... 

La Santa Biblia. . . traducida de las lenguas originales y cotejada dili-... 

Kursanov Parnes Loim Bull. Acad. Sci. USSR, Drv. Chem. Sci. 1966, 1245 West Donnelly Kooistra Doyle J. Org. Chem. 1973, 38, 2675. Sec also Fry Orfanopoulos Adlington Dili man Silverman J. Org. Chem. 1978, 43. 374 Olah Arvanaghi Ohannesian Synthesis 1986, 770. 

DILI, DNA single-strand breaks and DNA-protein eross-links, human + NT 242 Saladino et al. (1985)... 

The Lithcoa Co. has commercialized a series of dilithium reagents, DiLi-l (1A) (17), DiLi-3 (18), and DiLi-4 (19) (86) that also depend upon dimerization or oligomerization of hydrocarbon monomers for increased solubility. These materials have been applied to the synthesis of ABA copolymers. DiLi-l and DiLi-lA have the following structures (17). 

DiLi-3 (18) and DiLi-4 (19) are oligomeric aromatic, dilithium compounds in hexane-triethylamine solvent. 

The claimed distribution of mono-, di-, and trilithium compounds in DiLi-3 is 90 10 trace (86). However, other workers (87) have found it to be 22 64 13 by GC/MS analysis erratic results for this initiator have also been observed by other investigators (88). DiLi-4 is alleged to be more stable in storage than the other DiLi compounds, but confirming tests by independent laboratories are lacking. 

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