Models Systems Used to Study DILI

During the last decade, high content imaging and analysis (HCA) has emerged as a powerful tool for assessing molecular, cellular, and tissue-based toxicity (O Brien, 2014 Persson et al., 2014). Since HCA is based on automated imaging of cells or tissues, typically making use of 

FIGURE 8.7 Clustering of compounds positive for the lysosomal mass endpoint according to their pK and clogP. The majority of compounds were associated with cell loss (hlack circle), especially compounds with clogP 4. In contrast almost all compounds with clogP 2 showed no cell loss (gray circle) (Lu et al. (2012), pp. 613-620. Reproduced with permission of Elsevier). 

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