2.4- Dihydroxybenzoic acid / -Resorcylic

Resorcylic Acid, 3,5-Dinitro. See under 3,5-Dmitro-2,4-dihydroxybenzoic Acid in Vol 5, D1289-L... 

Experiment 6.156 2,4-DIHYDROXYBENZOIC ACID (fi-Resorcylic acid) l,3-(HO)2C6H4 2,4-(HO)2C6H3-C02H... 

P-resorcylic acid. (BRA 2,4-dihydroxyben-zene carboxylic acid 2,4-dihydroxybenzoic acid 4-hydroxysalicylic acid 4-carboxyresorci-nol). 

Phenolic Acids with More than One Hydroxyl Group Armstrong et al. (A14) have identified only one dihydroxylated phenolic acid in human urine, a-resorcylic acid (3,5-dihydroxybenzoic acid), the presence of which is very irregular. It must be recalled, however, that many of these acids are unstable and could have been decomposed by the alkaline solvent used by these authors and so be lost during the chromatographic separation. 

H.73) Benzoic acid, 3,5-dihydroxy-, 3,5-dihydroxybenzoic acid, a-resorcylic acid, 5-carboxyresorcinol [99-10-5]... 

Dihydroxybenzoic acid (/9-resorcylic acid) is alleged to be as active as sodium salicylate in rheumatic fever , but it does not affect vascular permeability in the mouse . 3,4-Dihydroxybenzoic acid (protocatechoic acid) is not active in rheumatic fever and is barely effective in inhibiting anaphylactic arthritis in the guinea-pig . When administered subcutaneously it does not reduce vascular permeability in the mouse , but reduces formalin-induced oedema in the mouse-foot . When given intraperitoneally,... 

Reid and his colleagues put forward the theory that the anti-inflammatory action of salicylate is due to its power to form metal chelate complexes. On this basis, it would be predicted that 2,6-dihydroxybenzoic acid (y-resorcylic acid) would be an even more potent anti-inflammatory agent. As already seen (page 77), early hopes of increased potency of this compound were not fulfilled. Nevertheless, the fact remains that many anti-inflammatory substances form coloured complexes with ferric ions in circumstances in which chemically related but inactive compounds do not . Salicylate, phenylbutazone and cinchophen behave in this way. Wiesel described metal chelate compounds of the anti-inflammatory glucocorticoids and showed that... 

Resorcylic Acid. See under Dihydroxybenzoic Acid and Derivatives in Vol 5, D1288-R... 

Dihydroxybenzoic acid (B-resorcylic acid) (Other values on Vol.3, p.209)... 

Bromo-2 4>dihydroxybenzoic Acid. See 3-Bromo-p-resorcylic Acid. 8>Bromo>2 4-dihydroxybenzolc Acid. See 5-Bromo- -resorcylic Acid. 

Kluge C, A Tschech, G Fuchs (1990) Anaerobic metabolism of resorcylic acids (m-dihydroxybenzoates) and resorcinol (1,3-benzenediol) in a fermenting and in a denitrifying bacterium. Arch Microbiol 155 68-74. 

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