5-Dihydroaeruginoic acid

Pyochelin is a non-ribosomal condensation product of salicyhc acid with two molecules of cysteine (289). Intermediates with one cysteine unit are aeruginoic acid (Fig. 21, 67) first isolated from Pseudomonas aeruginosa (390), and (-l-)-(5)-4,5-dihydroaeruginoic acid, from Pseudomonas fluorescens (57). Detailed studies (274a) suggest that M-hydroxybenzoyl-L-cysteine bound to the synthetase... 

Carmi R, Carmeli S, Levy E, Gough FJ (1994) (-t)-(5)-Dihydroaeruginoic Acid, an Inhibitor of Septoria tritici and other Phytopathogenic Fungi and Bacteria, Produced by Pseudomonas fluorescens. J Nat Prod 57 1200... 

Siderophores are low molecular weight compounds that chelate Fe3+ and transport it into the cell. Competition for iron appears to occur between pseudomonads and the rhizosphere bacteria and fungi. Three unusual siderophores with antifungal activity have been described from fluorescent pseudomonads, pyochelin (9), S-dihydroaeruginoic acid (10) and aeruginoic acid [13]. The importance of siderophores in biological control has been the subject of some debate [14]. 

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