Aeruginoic acid

Aeruginoic acid — see ThiazoIe-4-carboxyIic acid, 2-o-hydroxyphenyI-Aetiocobalamin, 4, 420 Aflatoxin B biosynthesis, 3, 876 Aflatoxin B, metabolism, 1, 245 toxicity, 1, 136 Aflatoxin G, toxicity, 3, 676 ... 

Pyochelin is a non-ribosomal condensation product of salicyhc acid with two molecules of cysteine (289). Intermediates with one cysteine unit are aeruginoic acid (Fig. 21, 67) first isolated from Pseudomonas aeruginosa (390), and (-l-)-(5)-4,5-dihydroaeruginoic acid, from Pseudomonas fluorescens (57). Detailed studies (274a) suggest that M-hydroxybenzoyl-L-cysteine bound to the synthetase... 

Yamada Y, Seki N, Kitahara T, Takahashi M, Matsui M (1970) Structure and Synthesis of Aeruginoic Acid (2-o-hydroxyphenylthiazole-4-carboxylic acid). Agric Biol Chem 34 780... 

Siderophores are low molecular weight compounds that chelate Fe3+ and transport it into the cell. Competition for iron appears to occur between pseudomonads and the rhizosphere bacteria and fungi. Three unusual siderophores with antifungal activity have been described from fluorescent pseudomonads, pyochelin (9), S-dihydroaeruginoic acid (10) and aeruginoic acid [13]. The importance of siderophores in biological control has been the subject of some debate [14]. 

The structure of aeruginoic acid, which is isolated from the culture medium of Pseudomonas aeruginosa, has been recognized as 2-u-hydroxy-phenylthiazole-4-carboxylic acid, and confirmed by an unequivocal synthesis of the Hantzsch type. ... 

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