Digoxin with cholestyramine

Cholestyramine and Colestipol. Other interactions involving complexation might be anticipated when cholestyramine (e.g., Questran) and colestipol (Coles-tid) are used. These resinous materials, which are not absorbed from the GI tract, bind with bile acids and prevent their reabsorption. In addition, cholestyramine and colestipol can bind with drugs (e.g., digoxin and warfarin) that are present in the GI tract. To minimize the possibility of an interaction, the interval between the administration of cholestyramine or colestipol and another drug should be as long as possible. 

Clinically important, potentially hazardous interactions with amiloride, aminoglycosides, amphotericin B, ampicillin, anisindione, anticoagulants, armodafinil, atorvastatin, azathioprine, azithromycin, bacampicillin, basiliximab, bezafibrate, bosentan, bupropion, carbenicillin, caspofungin, cholestyramine, clarithromycin, cloxacillin, co-trimoxazole, corticosteroids, cyclophosphamide, daclizumab, danazol, dicloxacillin, dicumarol, digoxin, diltiazem, disulfiram, echinacea, erythromycin, ethotoin, etoposide, ezetimibe, flunisolide, fluoxymesterone, fluvastatin, foscarnet, fosphenytoin, gemfibrozil, hemophilus B vaccine, HMG-CoA reductase inhibitors, imatinib, imipenem/cilastatin, influenza vaccines, ketoconazole, lanreotide, lopinavir, lovastatin, mephenytoin, methicillin, methoxsalen, methylphenidate, methylprednisolone, methyltestosterone, mezlocillin, mizolastine, mycophenolate, nafcillin, nisoldipine, NSAIDs, orlistat, oxacillin, penicillins, phellodendron, phenytoin, pravastatin, prednisolone, prednisone, pristinamycin, ranolazine, red rice yeast, rifabutin, rifampin, rifapentine, ritonavir, rosuvastatin, simvastatin, sirolimus, spironolactone, St John s wort, sulfacetamide, sulfadiazine, sulfamethoxazole, sulfisoxazole, sulfonamides, tacrolimus, telithromycin, tenoxicam, testosterone, ticarcillin, tolvaptan, trabectedin, triamterene, troleandomycin, ursodeoxycholic acid, vaccines, vecuronium, warfarin, zofenopril... 

Clinically important, potentially hazardous interactions with acitretin, aluminum hydroxide, amoxicillin, ampicillin, antacids, bacampicillin, betamethasone, bismuth, bromelain, calcium, carbenicillin, cholestyramine, doxacillin, corticosteroids, dairy products, dicloxacillin, didanosine, digoxin, food, glidazide, iron, isotretinoin, methicillin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, rocuronium, strontium ranelate, sucralfate, ticarcillin, vitamin A, zinc... 

The bile acids sequestrants, particularly cholestyramine, can decrease tlie absorption of numerous dru. For tliis reason, tlie bile acid sequestrants should be administered alone and otlier dru given at least 1 hour before or 4 hours after administration of the bile acid sequestrants. There is an increased risk of bleeding when tlie bile acid sequestrants are administered with oral anticoagulants. The dosage of the antico ulant is usually decreased. The bile acid sequestrants may bind with digoxin, tliiazide diuretics, penicillin, propranolol, tetracyclines, folic acid, and tlie thyroid hormone, resulting in decreased effects of th e dru. ... 

Meloxicam has been shown to have interactions with the following common medications ACE inhibitors, aspirin, cholestyramine, cimetidine, digoxin, furo-semide, hthium, methotrexate, warfarin [ 1 ]. 

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