Methyl digoxin

Intestinal absorption of digoxin is less complete compared to digitoxin. In order to improve absorption, acetylated- and methylated-digoxin derivates were developed. Digitoxin is metabolised in hepatic microsomal enzymes and can be cleared independently from renal function. The therapeutical serum level of digoxin is 0.5-2.0 ng/ml and 10-35 ng/ml of digitoxin. Steady state plateau of therapeutic plasma concentrations is reached after 4-5 half-life-times using standard daily doses [5]. 

Peruvoside (Fig. 4) is one of the major terpenoids produced by Thevetia peruviana, a small tree commonly used as an ornamental plant. As a cardiac glucoside, this natural product has been used to treat heart failure patients who are allergic to the commercial drug digoxin. Success in obtaining peruvoside from T peruviana was recently reported. Production of approximately 9.0 mg of peruvoside/L was achieved by elicitation of cell cultures with 100-mg/L methyl jasmonate. ... 

Synonyms. )5-Methyl Digoxin )5-Methyldigoxin Metildigoxin. Proprietary Names. Lanitop Metidi. 

Mediclear benzoyl peroxide, medigoxin [ban] (metildlgoxln [inn, jan]) is a methyl ether of digoxin. It is a cardiac glycoside and cardiac stimulant. Medihaler-lso Isoprenaline. 

SL Pippin, FI Marcus. Digoxin immunoassay with use of [3H]digoxin vs. [125]ty-rosine-methyl-ester of digoxin. Clin Chem 22 286, 1976. 

ER Garrett, PH Hinderling. Pharmacokinetics of beta methyl digoxin in healthy humans part 4 comparisons of radioimmunoassays total radioactivity and specific assays of beta methyl digoxin and digoxin in plasma. J Pharm Sci 66 806, 1977. 

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