Glucosides, cardiac

Asarum europeum L. According to Abdul menev, the root of this plant contains 1-7 per cent, of imcharacterised alkaloid, asarine. The root produces in frogs, rabbits and dogs, acceleration of respiration, nausea and emesis the cardiac activity of the leaves is thought to be due to a glucoside. (Farmatsiya, 1945, 8, No. 4, p. 39 Chem. Abstr., 1946, 40, 7411.)... 

Figure 9.14 A steroid glycoside. Digitoxenin is a cardiac-stimulating drug. It is a steroid glucoside in which a compound with a steroid structure is linked to a-D-glu-copyranose by condensation of the anomeric hydroxyl group on the carbohydrate and the alcohol group at position 5 on the steroid nucleus.

Peruvoside (Fig. 4) is one of the major terpenoids produced by Thevetia peruviana, a small tree commonly used as an ornamental plant. As a cardiac glucoside, this natural product has been used to treat heart failure patients who are allergic to the commercial drug digoxin. Success in obtaining peruvoside from T peruviana was recently reported. Production of approximately 9.0 mg of peruvoside/L was achieved by elicitation of cell cultures with 100-mg/L methyl jasmonate. ... 

Thalictrum foetidum L. Taiwan Tang Song Cao (whole plant) Thalfoetidine, thalpine, thalphinine, fetidine, flavonoid glycoside, saponin, cardiac glucoside, berberine, magnoflorine, palmitine, jatrorrhizine.56 Lower blood pressure, treat hepititis, cold, arthritis, intestinal infection. 

RED SQUILL has the same cardiac activity as the white variety. But the most pronounced effect is it s toxicity to rodents. Therefore it has been used as a rat poison and contains in addition to other constituents the glucosides scilliroside and scillir-ubroside. 

Koenigs-Knorr reactions have been used to prepare glycosides of natural products or otherwise of interest in biology as follows various cardiac glycosides (using Fetizon s reagentincluding 2,6-dideoxyhexopyranosides, a terpene D-glucoside, triterpene... 

---