Differential scanning calorimetry thermal stability prediction

There has been some interest in thermal analysis methods for permanence evaluation. An attempt was made to correlate various features of differential scanning calorimetry thermograms for a group of papers with their stability under oven aging. In some cases, the correlation coefficient was encouragingly high but the standard error of estimate showed that the relation was no more useful for predicting permanence than was pH. 

Thermal techniques such as isothermal calorimetry (ITC) and differential scanning calorimetry (DSC) have been used in formulation screens to predict the formulation with the greatest stability based on the assumption that excipients that increase the of the protein will stabilize the molecule at the recommended storage temperature. For example, a screen of preservatives performed during formulation development for interleukin-1 receptor found that the for the formulation... 

Thermoanalytical techniques have had a major application in the understanding of transitions in the skin and of drug penetration of the skin. The application of thermoanalytical techniques to prosthetics and implants is also discussed, as are recent DSC investigations of the oesophagus that provided the information on thermal stability required for successful stent implantation. The use of thermoanalytical techniques such as modulated temperature differential scanning calorimetry (MTDSC) has been be used to characterise polymeric material in order to determine whether there are interactions with drug substances to control and predict drug delivery. 

DIFFERENTIAL SCANNING CALORIMETRY (DSC) AS A MEANS OF PREDICTING THERMAL STABILITY (MOLAR... 

Abstract Thermal analytical methods such as differential scanning calorimetry (DSC) have been successfully applied to neat petrodiesel and engine oils in the last 25 years. This chapter shows how DSC and P-DSC (pressurized DSC) techniques can be used to compare, characterize, and predict some properties of alternative non-petroleum fuels, such as cold flow behavior and oxidative stability. These two properties are extremely important with respect to the operability, transport, and long-term storage of biodiesel fuel. It is shown that the quantity of unsaturated fatty acids in the fuel composition has an important impact on both properties. In addition, it is shown that the impact of fuel additives on the oxidative stability or the cold flow behavior of biodiesel can be studied by means of DSC and P-DSC techniques. Thermomicroscopy can also be used to study the cold flow behavior of biodiesel, giving information on the size and the morphology of crystals formed at low temperature. 

Richard MN, Dahn JR (1999) Accelerating rate calorimetry study on the thermal stability of lithium intercalated graphite in electrolyte. Modeling the results and predicting differential scanning calorimeter curves. J Electrochem Soc 146(6) 2078-2084... 

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