Diethofencarb

Diethofencarb can be used against benzimidazole-resistant strains of Botrytis spp. It also inhibits mitosis. It is quickly degraded in soil and in animals through oxidation of the 4-ethoxy group. 

Many herbicides with a common structure inhibit cell division  

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Phenylcarbamates, for example, diethofencarb (Figure 4.15) are active against fungi that are resistant to benzimidazoles. The two groups may... 

Dieldrin halogenated hydrocarbon Dienochlor halogenated hydrocarbon Diethatyl-ethyl amide Diethofencarb carbamate Diethyltoluamide amide Difenacoum coumarin... 

Isopropyl chlorpropham, diethofencarb, dinobuton, phenisopham, propham... 

Dichloroaniline 3.4 DCA) benzoyl prop-ethyl, diethofencarb, diuron, linuron, neburon, propanil, sulcofuron... 

N-phenyl-carbamates diethofencarb B-tubulin 19,23 Mutation in 6-tubulin gene(E198L) ... 

Leroux and Gredt reported that benzimidazole-resistant strains of Botrytis cinerea and Penicillium expansum exhibited negatively correlated cross resistance to herbicidal N-phenylcarbamates such as barban, chlorpropham, and chlorbufam (10, 11, 12). Based on their observation, Sumitomo scientists evaluated many examples of N-phenylcarbamates to search for compounds with potent fungitoxicity and no phytotoxicity. This effort was eventually successful, leading to new fungicides such as MDPC ( , 21 ) and diethofencarb (14, 23, 24) (Figure 2). 

Diethofencarb is highly toxic to benzimidazole-resistant isolates of B. cinerea, whereas its toxicity to the benzimidazole-sensitive isolates is weak. In contrast, MBC inhibited the growth of wild type isolates at a low concentration but had low toxicity to resistant isolates. In pot tests, diethofencarb was effective for gray mold caused by resistant isolates of Botrytis cinerea, but was not effective for wild type isolates. Diethofencarb has systematic activity in plants and both preventive and curative activity in controlling gray mold. 

Strains MBC Thiophanate- TBZ methyl Diethofencarb MDPC Barban... 

Cytological studies showed that diethofencarb-treated F914 conidia and MBC-treated wild type conidia showed a similar abnormal morphology, wherein the germ tubes were distorted and swollen. Diethofencarb had no effects on the morphology of the wild type strain. 

Diethofencarb affected the nuclear morphology of the F914 strain scattered nuclei were apparent. This was similar to the effect of MBC on the wild type strain. Thus the mode of action of diethofencarb in the F914 strain resembles that of MBC in the wild type strain. We noted similar findings in the case of B. cinerea treated with MBC and MDPC (21). 

To elucidate the mechanism of negatively correlated cross resistance and mode of action of diethofencarb, we isolated diethofencarb resistant mutants from mutagenized F914 strain. 

In another cross of moderately diethofencarb-resistant mutants (strain F421, F423 and F513) to the wild type strain, we obtained... 

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