Dictyodendrilla

Marine Sponge Dictyodendrilla verongiformis Bovine urine... 

Pyrrolo[2,3-c]carbazole alkaloids (see Schemes 2.70-2.72) isolated from the dark green marine sponge, Dictyodendrilla sp., showed inhibitory activity against bovine lens aldose reductase catalyzing the reduction of aldoses to polyols which, on accumulation in cells, may result in diabetes. These alkaloids could provide prevention from such ailments (250). 

Sato, A. Morishita, T. Shiraki, T. Yoshioka, S. Horikoshi, H. etal. (1993) Aldose reductase inhibitors from a marine sponge, Dictyodendrilla sp. J. Org. Chem., 58, 7632-4. 

Three aldose reductase inhibitors (490 492) were isolated from Dictyodendrilla sp. from Japan and their structures were determined by X-ray analysis and spectroscopic studies [418],... 

Tsuda M, Takahasi Y, Fromont J, Mikami Y, Kobayashi J (2005) Dendridine A, a Bis-indole Alkaloid from a Marine Sponge Dictyodendrilla Species. J Nat Prod 68 1277... 

Dictyodendrins A—E are a family of marine natural products, isolated by Fuse-tani and Matsunaga from the sponge Dictyodendrilla verongiformis (2003 JOC2765). Dictyodendrins have a unique pyrrolo[2,3-c]carbazole core. They exhibit strong telomerase inhibitory activity and their function exerts an important effect on relevant vital processes such as aging and cancer. 

Mantella Alkaloid 161, A-20082 Mantella Alkaloid 189, see T-20042 Mantella Alkaloid 191, A-20083 Mantella Alkaloid 317, A-20084 Aglaia odorata Alkaloid, A-20077 Callyspongia fibrosa Alkaloid, A-20078 Crotalaria retusa Alkaloid, A-10043 Dictyodendrilla Alkaloid, A-20081 Fromia monilis Alkaloid, A-30051 Pseudoceratina crassa Alkaloid, see B-30080 Zizyphus mucronata Alkaloid, A-20085 Alkaloid A, in B-I002I Mantella Alkaloid 384A, A-20086 Securidaca longipedunculata Alkaloid A, A-20087... 

Halisarcida Dictyodendrillidae Halisarcidae Acanthodendrilla, Dictyodendrilla, Igemella, Spongionella (= Megalopastas) Halisarca... 

This genus name is synonymous with Dictyodendrilla. 

Spongiolactone and omriolides A and B are three complex examples of the rearrangement of spongiane. Spongiolactone and the subsequently fotmd 3 -norspon-giolactone bear an imusual P-lactone moiety. Isolated from the Kenyan species Dictyodendrilla aff. retiara, omriolides show no particular biological activity (Rudi et al, 2005b). 

The most complex bis-indolic derivatives may be the sulfated pyrrolocarbazoles isolated from Dictyodendrilla sp. harvested in Japan. These highly branched derivatives, which are unnamed, are inhibitors of aldose reductase (Sato et al, 1993). 

Dictyodendrins A-E, isolated from Dictyodendrilla ver-ongiformis of Japanese origin, are similar to the above structures and are the first marine substances that inhibit telomerase (Warabi et al, 2003). 

In dendridine A, isolated from an unidentified spedes of the genus Dictyodendrilla of Japanese origin (Okinavra), the dimerization may result from a radical coupling between two bromoindolic parts. Dendridine A is antibacterial and antifungal, but only weakly cytotoxic (Tsuda et cd., 2005). 

Rudi, A., Erez, Y, Benayahu, Y, and Kashman, Y. (2005b) Omriolides A and B, two new rearranged spongian diterpenes from the marine sponge Dictyodendrilla aff. rctiara. Tetrahedron Lett., 46,8613-8616. 

Tran, N.H., Hooper, J.N.A., and Capon, R.J. (1995) New oxygenated sesquiterpenes from a Southern Australian marine sponge, Dictyodendrilla sp. Aust.J. Chem., 48, 1757-1760. 

Tsuda, M., Takahashi, Y., Eromont, J., Mikami, Y, and Kobayashi, J. (2005) Dendridrne A, a bis-indole alkaloid from a marine sponge Dictyodendrilla species./. Nat. Prod., 68, 1277-1278. 

Warabi, K., Matsunaga, S., Van Soest, R.W.M., and Fusetani. N. (2003) Dictyodendrins A-E, the first telomerase-inhibitory marine natural product from the sponge Dictyodendrilla veron formis. J. Org. Chem., 68, 2765-2770. 

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