Zizyphus mucronata

The peptide alkaloids of the mucronine-A type have a 15-membered ring system. Recently, ten representatives have been isolated from Zizyphus mucronata and from Z. abyssinica (28, 39) and recent re-... 

Plants containing these alkaloids have been often employed in folk medicine without however any knowledge as to a definite activity. Even the observed effects, if any, are not definitely ascribable to the cyclopeptides alone. It has been reported that Zizyphus mucronata is emplqyed by the natives of central and southern Africa in the treatment of diarrhea and dysentery. It is not impossible that such an effect may be ascribable to the alkaloids in view of their now known antibiotic... 

From the roots of Zizyphus mucronata, in addition to the known alkaloid mucronine D (23), two new cyclopeptide alkaloids 24 and 25 were isolated. The structures were elucidated by ID- and 2D-NMR techniques (48). A new cyclopeptide alkaloid, named mucronine J (53), was isolated together with known alkaloids abyssenine A and mucronine D (23) from the methylene chloride extract of the root bark of Z. mucronata (49). The structure of mucronine J was elucidated by mass spectrometry and ID and 2D-NMR techniques, and the solution conformation is proposed on the basis of NOE experiments in combination with MM2 calculations. Leaves of Zizyphus hysodrica were extracted with methanol and the different alkaloidal fractions gave a new compound, hysodricanine B, which is a cyclopeptide alkaloid (50). 

Sources Zizyphus mucronata (Rhamnaceae)-stem bark 132)... 

Abyssinine-A (142) Zizyphus mucronata (Rhamnaceae)-root bark... 

Tschesche, R., S.T. David, J. Uhlendorf, und H.-W. Fehlhaber Alkaloide aus Rhamnaceen, XV. Mucronin-D, ein weiteres cyclisches Peptid-Alkaloid aus Zizyphus mucronata Willd. Chem. Ber., 105, 3106 (1972). 

Barboni, L., P. Gariboldi, E. Torregiani, and L. Verotta Cyclopeptide Alkaloids from Zizyphus mucronata. Phytochemistry, 35, 1579 (1994). 

Fehlhaber, H.-W., J. Uhlendorf, S.T. David, and R. Tschesche Alkaloide aus Rhamnaceen, XII. Mucronin-A, -B und -C, Peptid-Alkaloide eines neuen Straktur-typs aus Zizyphus mucronata. Liebigs Ann. Chem., 759, 195 (1972). 

Auvm, C., R Lezenven, A. Blond, I. Augeven-Bour., J.-L. Pousset, B. Bodo, and J. Camara Mucronine J, a 14-Membered Cyclopeptide Alkaloid from Zizyphus mucronata. J. Nat. Prod., 59, 676 (1996). 

Mantella Alkaloid 161, A-20082 Mantella Alkaloid 189, see T-20042 Mantella Alkaloid 191, A-20083 Mantella Alkaloid 317, A-20084 Aglaia odorata Alkaloid, A-20077 Callyspongia fibrosa Alkaloid, A-20078 Crotalaria retusa Alkaloid, A-10043 Dictyodendrilla Alkaloid, A-20081 Fromia monilis Alkaloid, A-30051 Pseudoceratina crassa Alkaloid, see B-30080 Zizyphus mucronata Alkaloid, A-20085 Alkaloid A, in B-I002I Mantella Alkaloid 384A, A-20086 Securidaca longipedunculata Alkaloid A, A-20087... 

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