Aldose reductase inhibitor from Dictyodendrilla

Sato, A. Morishita, T. Shiraki, T. Yoshioka, S. Horikoshi, H. etal. (1993) Aldose reductase inhibitors from a marine sponge, Dictyodendrilla sp. J. Org. Chem., 58, 7632-4. 

Three aldose reductase inhibitors (490 492) were isolated from Dictyodendrilla sp. from Japan and their structures were determined by X-ray analysis and spectroscopic studies [418],... 

The most complex bis-indolic derivatives may be the sulfated pyrrolocarbazoles isolated from Dictyodendrilla sp. harvested in Japan. These highly branched derivatives, which are unnamed, are inhibitors of aldose reductase (Sato et al, 1993). 

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