Diclofenac Acetaminophen

Acetaminophen, bosentan, diclofenac, isoniazid, lovastatin, methyldopa, niacin, nefazodone, phenytoin, propylthiouracil, rifampin, trazodone, valproic acid, and venlafaxine... 

Anti-inflammatory drugs such as Ibuprofen, acetaminophen, diclofenac, atorvastatin, and hydrochlorthiazide were detected in the highest concentrations in samples from three WWTPs in Spain [93]. These compounds were present in average concentrations from 43 to 117 ng/g, 42 to 103 ng/g, 28 to 75 ng/g, 21 to 65 ng/g, and 29 to 126 ng/g, respectively. 

To sum up, it could be concluded, in a general extent, that risks are expected to be higher in areas with lower river flow and that compounds found to induce major hazards coincide with the ones found at the highest concentrations, such as the NSAIDs ibuprofen, diclofenac, naproxen and acetaminophen, lipid regulators, and antibiotics. 

Maechler, P., Kennedy, E. D., Wang, H., and Wollheim, C. B., 1998, Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell, J. Biol. Chem. 273, pp. 20770-20778 Masubuchi, Y., Nakayama, S., and Horie, T., 2002, Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats, Hepatology 35, pp. 544-551 Masubuchi, Y., Suda, C., and Horie, T., 2005, Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice, J. Hepatol. 42, pp. 110-116 Mathai, J.P., Germain, M., Marcellus, R. C., and Shore, G. C., 2002, Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53, Oncogene 21, pp. 2534-2544... 

Etodolac and five metabolites Acetaminophen, caffeine Ibuprofen, indoprofen, fenoprofen, ketoprofen, suprofen, diclofenac, metenamic acid Ibuprofen, naproxen, ketoprofen, suprofen Tricyclic antidepressants... 

Nonopioids Acetaminophen Ibuprofen Diclofenac Diflunisal Fenoprofen Naproxen sodium COX-2 inhibitors Opioids... 

Pain killers and anti-inflammatory agents may also cause a problem. Watch out for acetaminophen (Tylenol), naproxen (OTC Aleve or Rx Naprosyn), and ibuprofen (Advil, Motrin). The prescription-only anti-inflammatory drugs diclofenac (Voltaren) and indomethacin (Indocin) can also increase blood pressure. 

PIncus T, Koch GG, Sokka T, et al. A randomized, double-blind crossover clinical trial of diclofenac versus misoprostol versus acetaminophen in patients with osteoarthritis ofthe knees or hip. Arthritis Rheum 2001 44 1587-98. 

NSAIDs (nonsteroidal antiinflammatory drugs) Isolated cases of adverse neurological side effects have been seen with naproxen or phenylbutazone given with misoprostol. Misoprostol also increases the abdominal pain and other side effects of diclofenac and indometacin (indomethacin). Paracetamol (acetaminophen) intensifies pain if given with mifepristone and sulprostone used to induce abortion. 

Tables 95 and 96 give formulations for acetaminophen and diclofenac oral solutions that were developed on a laboratory scale, as typical examples. In the case of acetaminophen, povidone not only solubilizes the active substance, it also reduces its bitter taste [625]. Similar effects are described in the case of sul-famethoxazol and trimethoprim [21,625].

Analgesic, antiinflammatory Aminophenazone, aminopyrine, diclofenac, dexamethasone, dipyrone, phenylbutazone, phenylbutazone, indomethacin, fluocinolone acetonide, diclofenac, mefenamic acid, methyl salicylate, paracetamol, (acetaminophen) ibuprofen... 

Analgesic/ Anti-inflammatory Non-prescription treatment of colds, allergies, pain Prescription treatment of chronic pain, arthritis, migraines, etc. ASA (aspirin), ibuprofen, indomethacin, acetaminophen Naproxen, diclofenac, propyphenazone, codeine 33, 40, 55, 61, 62... 

DMSO X 5 X Sulfasalazine, furosemide, atenolol, acetaminophen, propranolol, theophylline, diclofenac, metoprolol, antipyrine, naproxen Watanabe etak, 2004... 

The OAT proteins play a critical role in the excretion and detoxification of a wide variety of drugs, toxins, hormones and neurotransmitter metabolites. A number of common non-steroid anti-inflammatory drugs (NSAID), including acetyl salicylate and salicylate, acetaminophen, diclofenac, ibuprofen, ketoprofen, indomethacin, and naproxen, are substrates of one or more OAT isoforms, so that there can be significant interactions between NSAlDs and other drugs. The 3-lactam antibiotics (penicillins, cephalosporins and penems) and the antiviral nucleosides adefovir, cidofovir,... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

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