Acetaminophen metabolite

The chemical and toxicologic characterization of the electrophilic nature of the reactive acetaminophen metabolite has led to the development of effective antidotes—cysteamine and /V-acetylcysteine. Administration of /V-acetylcysteine (the safer... 

Acetaminophen [NE] Increased formation of hepatotoxic acetaminophen metabolites (in chronic alcoholics). 

Wilson, J.M. Slattery, J.T. Forte, A.J. Nelson, S.D. Analysis of acetaminophen metabolites in urine by high-performance liquid chromatography with UV and amperometric detection. J. Chromatogr. 1982, 227, 453-462. 

Transient receptor potential channel TRPVl receptors Acetaminophen metabolite (inhibitor)... 

Spraul, M. Freund, A.S. Nast, N.E. Withers, R.S. Maas, W.E. Corcoran, O. Advancing NMR Sensitivity for LC-NMR-MS Using a Cryoflow Probe Application to the Analysis of Acetaminophen Metabolites in Urine, AnaZ. Chem. 75, 1546-1551 (2003). 

FIGURE 10-2. Pathway of acetaminophen metabolism and basis for hepatotoxicity. (NAPQI, N-acetyl-p-benzoquInone-lmlne, a reactive acetaminophen metabolite.)... 

Slitt, A. L., Cherrington, N. J., Maher, J. M., and Klaassen, C. D. (2003) Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metab. Dispos. 31, 1176-1186. 

Figure 2. Metabolism of reactive paracetamol (acetaminophen) metabolite.

Acetaminophen-induced hepatic toxicity (see Chapter 26) has been associated with alcoholic cirrhosis as a result of alcohol-induced increases in microsomal production of toxic acetaminophen metabolites. Hepatitis C appears to be an important cofactor in the development of end-stage... 

Spraul M, Freund AS, Nast RE, Withers RS, Maas WE, Corcoran O. Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe application to the analysis of acetaminophen metabolites in urine. Anal Chem 2003 75(6) 1536-1541. 

Single doses of acetaminophen (1 g) administered during three months supplementation of aged garlic extract (equivalent to 6 cloves/day) showed that peak plasma concentrations of acetaminophen and acetaminophen metabolites were increased and renal clearance was decreased by garlic coadministration (Gwilt et al. 1994). 

Senter PD, Al-Abed Y, Metz CN et al. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc Natl Acad Sci USA 2002 99 144-149. 

M. Hamilton and P.T. Kissinger, Determination of acetaminophen metabolites in urine by liquid chromatography/electrochemistry. Anal. Biochem., 1982, 125, 143-148. 

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