Dichroa

The antimalarial properties attributed to preparations from Dichroa febrifuga by the Chinese were confirmed about 1944 and two alkaloids, febrifugine (999) and isofebrifugine (1000), were isolated eventually. After difficult structural elucidations, syntheses of ( )-febrifugine followed it proved to be half as active as the natural material, itself far better than quinine, but the therapeutic index was disappointingly low (67HC(24-l)490). [Pg.148]

In addition to lupines, poison-hemlock and Nicotiana spp., other plant species of the genera Genista, Prosopis, Lobelia, Cytisus, Sophora, Pinus, Punica, Duboisia, Sedum, Withania, Carica, Hydrangea, Dichroa, Cassia, Ammondendron, Liparia, and Colidium contain potentially toxic and teratogenic piperidine alkaloids. Many plant species or varieties from these genera may be included in animal and human diets (Keeler and Crowe, 1984). [Pg.26]

The EtOH extract of Ipomoea dichroa Choisy was fractionated into different organic solvents. The n-hexane-soluble fraction was resolved by column chromatography to afford dichrosides A-D. The major component dichroside D (hexadecanoic acid, (115)-[(0-6-deoxy-a-L-mannopyranosyl-(1 3)-0-[ S-D-glucopyranosyl-(l—>4)]-0-6-deoxy-a-L-mannopyranosyl-(1 4)-0-6-deoxy-a-L-mannopyranosyl-(l—>2)-6-deoxy-a-L-mannopyranosyl)oxy]) was subjected to catalytic hydrogenation. [Pg.102]

Harrison DA, Madhusudan KP, Kulshreshtha DK (1985) Structure of Dichroside D, a Fatty Acid Glycoside from Ipomoea dichroa. Carbohyd Res 143 207... [Pg.150]

Adamia chinensis Gard. et Champ. A. cyanea Wall. A. versicolof Fortune (Syn. Dichroa febrifuga) Chang Shan (Chinese quinine, fever flower) (root) Alpha-dichroine, beta-dichroine, gamma-dichroine.49 This herb is toxic. Antimalarial, antipyretic. [Pg.20]

Dichroa febrifuga Lour., D. cyanitis Miq., D. febrifuga Lour., D. latifolia Miq., Adamia cyanea Wall., A. versicolof Fortune... [Pg.342]

Xanthium chinense, X. japonicum, X. mongolicum, X sibiricum, X. strumarium Dichroa cyanitis, D. febrifuga, D. latifolia Dichroa cyanitis, D. febrifuga, D. latifolia Dichroa cyanitis, D. febrifuga, D. latifolia... [Pg.416]

Chang Shan (Dichroae febrifugae radix) is contraindicated with onion. [Pg.29]

For malarial diseases, add Herba Artemisiae Apiaceae (QingHao) and Radix Dichroae Febrifugae (Chang Shan). [Pg.39]

Febrifugine has a history as a malaria remedy which dates back to the first recorded use of Ch ang Shan in China, 200 B.C. It is an alkaloid which is apparently fairly widely distributed in the roots and leaves of plants of the family Saxifragaceae, and has been isolated both from the leaves of the common hydrangea in the United States and from the roots of Dichroa febrifuga Lour. The alleged antimalarial activity of the latter crude plant material has been confirmed by a number of modem investigators (93, 96-99). As a consequence of the careful and independent studies of both American and Chinese workers (100-106), the active alkaloid has been... [Pg.156]

Apparently, febrifugine (41) and isofebrifugine (42) isolated from Dichroa febrifuga have anti-moth activity. Peganum harmala has been shown to elaborate a new alkaloid, pegalol (37 R = H, OH, R = H). The seasonal patterns of peganine (37 R = H2, R = OH) distribution in the roots and ripe seeds of P. harmala have been determined. ... [Pg.113]

Isofebrifugine C16H19N3O3 154-156 129-131 + 120 (148-150) Hydrangea umbellata Rheder (151) Dichroa febrifuga Lour. [Pg.134]

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