Transporters dicarboxylate

Six S, SC Andrews, G Unden, JR Guest (1994) Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membrane transporters (Dcua and Dcub) distinct from the aerobic dicarboxylate transport system (Dcf). J Bacterial 176 6470-6478. 

Some transporters such as Na+-dependent dicarboxylate transporter (NADC1), Na+-dependent bicarbonate transporter 2 (SBC2), Na+-dependent bicarbonate transporter HNBC1, several ion transporters, and channels are also expressed in the intestinal tissues [4]. 

BarA sensor kinase (sensory histidine kinase) <269> [16, 257] C4-dicarboxylate transport sensor protein dctB <61, 66> [77, 88, 89, 90, 91, 92]... 

Ronson, G.W Astwood, P.M. Nixon, B.T. Ausubel, EM. Deduced products of G4-dicarboxylate transport regulatory genes of Rhizobium legu-... 

Watson, R.J. Analysis of the G4-dicarboxylate transport genes of Rhizobium meliloti nucleotide sequence and deduced products of dctA, dctB, and dctD. Mol. Plant Microbe Interact., 3, 174-181 (1990)... 

HambUn, M.J. Shaw, J.C. Kelly, D.J. Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus. Mol. Cen. Cenet., 237, 215-224 (1993)... 

Watson, R.J. Chan, Y.-K. Wheatcroft, R., Yang, A.-F. Han, S. (1988). Rhizobium meliloti genes required for C-4-dicarboxylate transport and symbiotic nitrogen fixation are located on a megaplasmid. Journal of Bacteriology 170, 927-34. 

Oatl was cloned by expression cloning using X. laevis oocytes by coexpression of sodium-dicarboxylate transporter, which forms outward concentration gradient of dicarboxylate to drive Oatl-mediated uptake (129). Oatl is predominantly expressed in the kidney, where it is localized in basolateral membrane of the proximal tubules (130). Oatl is a multispecific transporter, and it accepts PAH, a typical substrate for this transporter, and relatively hydrophilic small organic... 

Some mutants of D. melanogaster with extended lifespans have a defective insulin / IGF signaling pathway. The methuselah mutant, whose lifespan is 35% greater than average, appears to involve a G-protein-coupled transmembrane receptor. Mutation of an insulin receptor homolog extends lifespan, apparently by causing a juvenile hormone deficiency. Drosophila lifespan is also lengthened by mutation of a transmembrane dicarboxylate transporter or by overexpression of a protein repair carboxyl methyltransferase (p. 594). ... 

Regulation by the pH of the Ca /K transport selectivity has been achieved with the dicarboxylic ligand (13) at high pH the dicarboxylate transports Ca, whereas at low pH only the mono-carboxylate is formed, i.e. the transport of K is dominant in these conditions <83PNA(80)6426>. pH-dependent metal ion selectivity has also been observed with compound (14) <86IC396>. 

Youn JW, Jolkver E, Kramer R, Marin K, Wendisch VF. (2009). Characterization of the dicarboxylate transporter DctA in Corynebacterium glutamicum. J Bacteriol, 191, 5480-5488. 

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