Dicarboxyiic acids

Blauc s rule Ail dicarboxyiic acids, with the exception of oxalic and malonic acids, up to... 

IsoxazoIe-5-carboxyIic acid anilide, 3,4-diphenyI-synthesis, 6, 86 Isoxazolecarboxylic acids applications, 6, 128 IR spectra, 6, 5 potentiometry, 6, 11 reactions, 6, 52 synthesis, 6,27, 85-86 thermochemistry, 6, 10 IsoxazoIe-3,4-dicarboxyIic acid esters... 

IsoxazoIe-3,5-dicarboxyIic acid 4-subs tituted synthesis, 6, 77, 85... 

Isoxazole-3,5-dicarboxyIic acid, 4-hydroxy-diethyl ester synthesis, 6, 85, 87 synthesis, 6, 66... 

When a diamine (molecule containing two NH2 groups) reacts with a dicarboxyiic acid (two COOH groups), a polyamide is formed. This condensation polymerization is entirely analogous to that used to make polyesters. In this case, the NH2 group of the diamine reacts with the COOH group of the dicarboxyiic acid ... 

Explosions, Unexpected. POCl3 Explodes in Lab, A severe and unexplained expln of a bottle contg recovered phosphorus oxychloride occurred at the Uni of Arizona chem lab. Dr L. Plummer was prepg the diacid chloride of ferrocene-l,l-dicarboxyIic acid, using a mixt of PC15 phosphorus oxychloride. He had just distilled (under reduced press) the oxychloride from the reaction mixt. The recovered phosphorus oxychloride was poured into a 500-ml brown bottle contg some of the compd recovered from earlier, similar reactions. Some of the recovered compd had been standing for ca 3 months... 

Furan-3,4-dicarboxyIic acid [3387-26-6] M 156.1, m 217-218°. Crystd from water. 

Pyridine-3,4-dicarboxyIic acid [490-11-9] M 167.1, m256°. Crystd from dilute aqueous HC1. o... 

Furans have been prepared from 1,4-dialdehydes, usually in the more accessible acetal form by acid catalyzed ring closure. Using this approach, furan-3,4-dicarboxyIic acid has been obtained in 70% yield as the ester from 2-(dialkoxymethyl)-l-formyl succinic ester (54JOC1671). c/s-2-Butene-l,4-diol on oxidation to the monoaldehyde is cyclized to furan (61 ACSll77). The acetals (83) and (84) have been converted to the corresponding furan... 

It has been shown that thiophene-2,3-dicarboxyIic acid is preferentially esterified in the 2-position also, selective hydrolysis of the 2,3-diester results in the formation of the 2-carboxylic acid. Decarboxylation during electrophilic substitution is a well-recognized... 

Alkali treatment of proteins is becoming more common in the food industry and may result in several undesirable reactions. When cystine is treated with calcium hydroxide, it is transformed into amino-acrylic acid, hydrogen sulfide, free sulfur, and 2-methyl thia-zoIidine-2,4-dicarboxyIic acid as follows ... 

Acetate esters are common by-products of LTA decarboxylation procedures. The yield of diese products, derived from further oxidation of the alkyl radical and quenching of the subsequent carbocation by acetate ions, can be improved by working in acetic acid in die presence of potassium acetate. Selective monodecarboxylation of 1,3- and 1,4-dicarboxyIic acids leads, via an analogous mechanism, to y- and 8-lactones in mo rate to good yields, as illustrate in equation (39). 

Pyruvic acid and isatins gave quinoline-2,4-dicarboxyIic acids. 

Hydrazine iV,Af -dicarboxyIic acid diamide [110-21-4] M 116.1, m 248 . Crystd from water and... 

Terephthalic acid (benzene-l,4-dicarboxyIic acid) [100-21-0] M 166.1, m sublimes >300° without melting, pKj 3.4, pK2 4.34. Purified via the sodium salt which, after crystn from water, was reconverted to the acid by acidification with mineral acid. 

BiquinoIin-4,4 -dicarboxyIic acid dipotassium salt [63451-34-3] M 420.51. Recryst from H2O. The Cu salt has X ax 1 562nm. [Anal Biochem 56 4409 1973.]... 

Malic acid, C4Hh05, has been isolated from apples. Since this compound reacts with 2 molar equivalents of base, it is a dicarboxyiic acid. 

Draw all possible stereoisomers of cyclobutane-1,2-dicarboxyiic acid, and indicate the interrelationships. Which, if any, are optically active Do the same for cyclobu-tane-l,3-dicarboxylic acid. 

---