4.5- Dicarboxy-2-ethyl

Hydroxy-4(bzw. 3)-nitro-benzyl]-E16a, 221 (N-Deacylier.) Imidazol 4,5-Dicarboxy- 2-ethyl- E8c. 13 [HOOC — CH(OH) —... 

This enzyme [EC 4.3.2.2], also referred to as adenylosuc-cinase, catalyzes the conversion of A -(l,2-dicarboxy-ethyl)AMP (or, adenylosuccinate) to yield fumarate and AMP. The enzyme will also convert l-(5-phosphoribo-syl)-4-(A-succinocarboxamide)-5-aminoimidazole to 5 -phosphoribosyl-5-amino-4-imidazolecarboxamide. 

Figuro 41 Synthesis of 7V-[(2 -hydroxy-2, 3 -dicarboxy)ethyl]chitosan from chitosan.

Gruber JV, Rutar V, Bandekar J, Konish PN. Synthesis of Al-[(3 -Hydroxy-2, 3-dicarboxy)-ethyl] chitosan a new, water-soluble chitosan derivative. Macromolecules 1995 28 8865-8867. 

Gruber JV. Synthesis of V-[(3 -Hydroxy-2, 3 -dicarboxy)ethyl] chitosan a new water-soluble, amphoteric chitosan derivative. In Domard A, Jeuniaux C, MuzzareUi R, Roberts G, eds. Advances in Chitin Science, Vol 1. Lyon Jacques Andre, 1996 230-235. 

Tetrasodlum N-( 1,2-dicarboxy-ethyl)-N-octadecyl sulfosuccln-amate... 

The reaction of ethyl diazoacetate (312) with sodium or potassium ethoxide was studied by Curtius and his coworkers (08CB3140). They isolated a compound for which they proposed structure (316), which is a metal salt of diethyl l,6-dihydro-l,2,4,5-tetrazine-3,6-dicarboxy-late complexed with one mole of the ethoxide used. 

Benzyloxycarboiiylarmno-2-(pentafluorophcnoxycarbonyl-cthyl)-3-[2-benzyloxyciirbonyl-2-(5-benzyloxycarbonylamino-2-tert,-butyloxycarbonylamino-4-hydroxy-penlanoylamino)-ethyl]-4,4 -bis-[benzyloxy]- ElOb, 584 (Arf — OH - ArF —O —CO-R) 4,4 -Bis-[l-(3,4-dicarboxy-phenyl)-... 

Thiazol-3-ium, 3-ethyl-2-[A2, 3-(3 -ethyl-2 -thiazolylidene)-3-ylidene-1 -propen]-1 -yl-visible, 1, 345 (B-76MI11201) Thiazolo[2,3-a]isoquinolinium, anhydro-3-(4-bromophenyl)-2-mercapto-X-ray, 6, 669 <67JCS(B)1117> Thiazolo[2,3-/][l,6]naphthyridin-4-ium, anhydro-3,8-dicarboxy-6-hydroxy-X-ray, 6, 669 (76JA299)... 

The general interests in chelation of metals have continued to lead to new forms of polyaminopolycarboxylic acids. Examination of the acid dissociation constant of ethyl-ene-bis-N,N -(2,6-dicarboxy)piperidine (9) showed that they were nearly identical with those of EDTA. However, the formation constants for metal chelates of (9) are lower by 0.5 to 3.7 log 3 units. 

Nicotinic arid Paraldehyde + NH3 - 2 methyl 5 ethyl pyridine + HN03 2.5 dicarboxy pyridine - nicotinic acid... 

Benzoesaure 3,4-Dimethoxy-2-hydroxy- Vl/3, 66 4H-Pyran 2,6-Dicarboxy-4-ethyl-Vl/4, 100... 

The condensation of diethyl succinate in the presence of ethanolic sodium ethylate and DBU in xylene at 80-100°C gave diethyl 2,5-dihydroxy-1,4-cyclohexadiene-1,4-dicarboxy late (77 J AP(K)5739). 

From 1-tert-butyl 2-ethyl S-acetyl-6-oxopiperidine-l,2-dicarboxy-late. Treatment of Boc-protected 5-acetyl-6-oxopiperidine-2-carboxylic acid ethyl ester 218 with a 64% aqueous solution of hydrazine in acetonitrile gave (R,S)-2-ferf-butoxycarbonylamino-4-(3-oxopyrazol-4-yl)butyric acid 219, in 67% yield. The corresponding 1-methyl derivative 220 was obtained in only 17% yield by treating 218 with methylhydrazine under similar conditions (99EJMC967) (Scheme 49). 

Another synthesis of emetine has also been reported. The key intermediate (LI R = C0aEt) was obtained in five main steps from the reaction product of an excess of ethyl oxalate with 3,4-dimethoxy-phonethylamine. The condensation of 2-carbethoxytetrahydroiso-quinoline with a-ethyl-/3,/3-dicarbethoxypropionyl chloride yielded a triscarboxy derivative which on hydrolysis, decarboxylation (to a dicarboxy derivative), esterification, and Dieckmann condensation generated a diketo derivative. The last w as converted to LI (R = COaEt) by another series of reactions in which a keto group was transformed to a methylene via a carbinol, its mesylate, its benzylmercapto derivative, and finally reduction of the last with Raney nickel. 

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