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1.3- dicarbonylic compounds

The synthesis of pyrazolcs starting from a hydrazine and a 1,3-dicarbonyl compound is a well established reaction in organic synthesis. If a mono-suhstituted hydrazine is reacted with an unsymmctrically substituted 1,3-dicarbonyl compound, two different pyrazole products which arc regioisomers could he formed (sec figure 10.3-2). [Pg.545]

Analysis Taking the heterocychc part first, we can remove the two heteroatoms as hydroxylamine (the approach of frames 258-261) to give us a 1,3-dicarbonyl compound. [Pg.130]

Butyl vinyl ether reacts with aroyl chlorides using Pd(OAc)2 without a ligand to give the unsaturated ketone 839, which is a precursor of a 1-aryl-1,3-dicarbonyl compound. The reaction is regioselective /3-attack. Addition of PhjP inhibits the reaction[718]. [Pg.253]

Most of the reactions of ester enolates described so far have centered on stabilized eno lates derived from 1 3 dicarbonyl compounds such as diethyl malonate and ethyl ace toacetate Although the synthetic value of these and related stabilized enolates is clear chemists have long been interested m extending the usefulness of nonstabilized enolates derived from simple esters Consider the deprotonation of an ester as represented by the acid—base reaction... [Pg.902]

Insertion Reactions. Isocyanates also may undergo iasertion reactions with C—H bonds. Acidic compounds, such as 1,3-dicarbonyl compounds (6), react readily at room temperature to form carboxyamides. At higher temperatures carboxyamides frequentiy undergo secondary reactions leading to cyclized products (33,34). [Pg.449]

The addition of 1,3-dicarbonyl compounds to /3-chloroazoalkenes is the basis of a pyrrole synthesis (Scheme 70a) 81TL1059). Pyrroles are also obtained by the reaction of enamines with azoalkenes (Scheme 70b) (79TL2969,81TL1475), and the copper(II) chloride catalyzed addition of 1,3-dicarbonyl compounds to arylazoalkenes (Scheme 70c) (82JOC684). [Pg.128]

Isoxazoles are susceptible to attack by nucleophiles, the reactions involving displacement of a substituent, addition to the ring, or proton abstraction with subsequent ring-opening. Isoxazolium salts are even more susceptible to attack by a variety of nucleophiles, providing useful applications of the isoxazole nucleus in organic synthesis. Especially useful is the reductive cleavage of isoxazoles, which may be considered as masked 1,3-dicarbonyl compounds or enaminoketones. [Pg.12]

C NMR, 6, 550 LCAO-MO calculations, 6, 557 melting point, 6, 555 methylation, 6, 565 reactions, 6, 558 with bromine, 6, 560 with 1,3-dicarbonyl compounds, 6, 565 with nitrous acid, 6, 565 ring opening, 6, 561 solubility, 6, 555 5-substituted... [Pg.861]

Formation o( oleltns by coupling or cross coupling of ketones, mediated by low valent titanium Also coupling ol enol ethers of 1,3-dicarbonyl compounds. [Pg.249]

The carbonyl group forms a number of other very stable derivatives. They are less used as protective groups because of the greater difficulty involved in their removal. Such derivatives include cyanohydrins, hydrazones, imines, oximes, and semicarbazones. Enol ethers are used to protect one carbonyl group in a 1,2- or 1,3-dicarbonyl compound. [Pg.177]

The reaction of tnfluoromethyl-substituted A -acyl umnes toward nucleophiles in many aspects parallels that of the parent polyfluoro ketones Heteronucleophiles and carbon nucleophiles, such as enarmnes [37, 38], enol ethers [38, 39, 40], hydrogen cyanide [34], tnmethylsilylcarbomlnle [2,47], alkynes [42], electron-nch heterocycles [43], 1,3-dicarbonyl compounds [44], organolithium compounds [45, 46, 47, 48], and Gngnard compounds [49,50], readily undergo hydroxyalkylation with hexafluoroace-tone and amidoalkylation with acyl imines denved from hexafluoroacetone... [Pg.842]

The chloride of triflic acid (trifluoromethanesulfonyl chloride) is an effective sulfonylating agent Like triflic anhydride, it usually reacts with alcohols and other nucleophiles with the formation of the corresponding derivatives of tnflic acid [69] However, in some reactions, it acts as a chlorinating reagent [98] The reactions of tnfluoromethanesulfonyl chloride with 1,3-dicarbonyl compounds or some carboxylic esters in the presence of a base result m the formation of chlonnated products in high yields (equation 49)... [Pg.960]

The Gewald aminothiophene synthesis involves the condensation of aldehydes, ketones, or 1,3-dicarbonyl compounds 1 with activated nitriles such as malononitrile or cyanoacetic esters 2 and elemental sulfur in the presence of an amine to afford the corresponding 2-aminothiophene 3. ... [Pg.193]

Tetrasubstituted thiophenes obtained by the Gewald reaction serve as templates for structural diversification and semi-automated library synthesis. Thiophene 31, prepared from 3-ketoester 29 and t-butylcyanoacetate 30, could be selectively derivatized at three of the four substituents to maximize library diversity. This procedure represents an improvement over previously published methods for utilizing 1,3-dicarbonyl compounds in the Gewald reaction. [Pg.196]

In 1965, Haddadin and Issidorides, at the American University of Beirut, observed that combining 1 with morpholinocyclohexene 5 in methanol afforded quinoxaline-1,4-dioxide 6 in 48% yield." Shortly thereafter, the same authors reported that 1 also reacts with 1,3-dicarbonyl compound 7 in the presence of triethylamine to give the quinoxaline-1,4-dioxide 8 in 38% yield. This reaction has been referred to in the chemical literature as the Beirut reaction to acknowledge the city in which it was discovered. [Pg.504]

The condensation of 1,3-dicarbonyl compounds 1 with amidines 2 catalyzed by acids or bases to give pyrimidine derivatives 3 is regarded as the Pinner pyrimidine synthesis. ... [Pg.536]

Many pyrimidine derivatives have been prepared via the Pinner procedure. Amidines react with 1,3-dicarbonyl compounds to form 2, 4, 6-trisubstituted pyrimidines. ... [Pg.537]

Ghosh et al reported a modified procedure for the preparation of highly substituted pyrimidines by condensation of a 1,3-dicarbonyl compound 22 with tri-(trimethylsilyl)amidine (23) in good yield as compared to the lesser yield obtained from employing a classical Pinner procedure. ... [Pg.538]

Ring-chain tautomerism of hydrazones of 1,3-dicarbonyl compounds 99MI21. [Pg.205]

Another important application is the acylation of enamines 1 with an acyl chloride 9 to give a 1,3-dicarbonyl compound as final product ... [Pg.269]


See other pages where 1.3- dicarbonylic compounds is mentioned: [Pg.30]    [Pg.11]    [Pg.248]    [Pg.187]    [Pg.762]    [Pg.477]    [Pg.42]    [Pg.303]    [Pg.278]    [Pg.61]    [Pg.62]    [Pg.603]    [Pg.537]    [Pg.762]    [Pg.189]    [Pg.193]    [Pg.292]    [Pg.160]    [Pg.175]    [Pg.45]   
See also in sourсe #XX -- [ Pg.764 ]




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1 ,3- Dicarbonyl compounds Michael addition with

1 ,3- Dicarbonyl compounds cleavage

1 ,3- Dicarbonyl compounds synthesis

1,3-Dicarbonyl compounds acidity

1,3-Dicarbonyl compounds asymmetric Michael addition

1,3-Dicarbonyl compounds cascades

1,3-Dicarbonyl compounds chiral metal complexes

1,3-Dicarbonyl compounds enantioselective Michael addition

1,3-Dicarbonyl compounds warfarin anticoagulants

1,3-Dicarbonyl compounds, keto/enol

1,3-Dicarbonyl compounds, keto/enol tautomerism

1,3-Dicarbonyl type compounds carbon acidity

1,3-Dicarbonyl type compounds dianions

1,3-dicarbonyl compounds Michael reactions

1,3-dicarbonyl compounds cyclopropanation

1,3-dicarbonyl compounds enones

1,3-dicarbonyl compounds nitroalkenes

1- Diazo-2,5-dicarbonyl compounds

1.2- Diaminobenzenes, reaction with 1,2-dicarbonyl compounds

1.2- Dicarbonyl compounds

1.2- Dicarbonyl compounds

1.2- Dicarbonyl compounds Baeyer-Villiger reaction

1.2- Dicarbonyl compounds diazo-coupling reactions

1.2- Dicarbonyl compounds from 1,3-dithianes

1.2- Dicarbonyl compounds from acyl halides

1.2- Dicarbonyl compounds from alkenes

1.2- Dicarbonyl compounds from alkyl halides

1.2- Dicarbonyl compounds from alkynes

1.2- Dicarbonyl compounds from esters

1.2- Dicarbonyl compounds from imines

1.2- Dicarbonyl compounds from ketones

1.2- Dicarbonyl compounds furans from

1.2- Dicarbonyl compounds oxidation

1.2- Dicarbonyl compounds oxidative cleavage

1.2- Dicarbonyl compounds pyridazines from

1.2- Dicarbonyl compounds, formation

1.3- Dicarbonyl compounds a-alk-l-ynylation

1.3- Dicarbonyl compounds dianions

1.3- Dicarbonyl compounds dienolates

1.3- Dicarbonyl compounds from acetals

1.3- Dicarbonyl compounds from aldehydes

1.3- Dicarbonyl compounds from enamines

1.3- Dicarbonyl compounds from ketals

1.3- Dicarbonyl compounds from nitriles

1.3- Dicarbonyl compounds oxidations, manganese acetate

1.3- Dicarbonyl compounds selenenylation

1.3- Dicarbonyl compounds y-alkylation

1.3- Dicarbonyl compounds, 6-nitroHenry reaction intramolecular

1.3- Dicarbonyl compounds, alkylation

1.3- Dicarbonyl compounds, furans

1.3- Dicarbonyl compounds, oxidative

1.3- Dicarbonyl compounds, oxidative dimerization

1.3- Dicarbonyl compounds, reaction with amidines

1.3- Dicarbonyl compounds. See

1.3- dicarbonyl compounds amines

1.3- dicarbonyl compounds bonds

1.3- dicarbonyl compounds continued

1.3- dicarbonyl compounds cyclic

1.3- dicarbonyl compounds derivatives

1.3- dicarbonyl compounds ethers

1.3- dicarbonyl compounds nucleophiles

1.3- dicarbonyl compounds propargylation

1.3- dicarbonyl compounds reaction with

1.3- dicarbonyl compounds reaction with benzyl

1.3- dicarbonyl compounds reaction with benzylic

1.3- dicarbonyl compounds reaction with cycloalkene

1.3- dicarbonyl compounds reaction with phenyl

1.3- dicarbonyl compounds reaction with propargylic

1.3- dicarbonyl compounds reaction with tertiary

1.3- dicarbonyl compounds reaction with toluene

1.3- dicarbonyl compounds sulfide

1.4- Dicarbonyl compounds dehydrogenation

1.4- Dicarbonyl compounds from 2-ethyl-5-methyl

1.4- Dicarbonyl compounds from carboxylic acids

1.4- Dicarbonyl compounds from enolate anions

1.4- Dicarbonyl compounds from silyl enol ethers

1.4- Dicarbonyl compounds from unsaturated ketones

1.4- Dicarbonyl compounds use of cyclopropanes

1.4- Dicarbonyl compounds use of selenium dioxide

1.4- Dicarbonyl compounds via Wacker oxidation

1.4- Dicarbonyl compounds, Stetter reaction

1.4- Dicarbonyl compounds, reaction with hydrazines

1.4- dicarbonyl compounds, from succinic

1.5- Dicarbonyl compounds conjugate addition

1.5- Dicarbonyl compounds from hydrazones

1.5- Dicarbonyl compounds via Claisen rearrangement

1.5- Dicarbonyl compounds, synthesis Michael reaction

1.5- dicarbonyl compounds, cyclization

1.6- Dicarbonyl type compounds: synthesis

2-diazo-l,3-dicarbonyl compounds

5.6- Diaminopyrimidine, reaction with 1,2-dicarbonyl compounds

6-Dicarbonyl compounds enol form

A-Dicarbonyl compounds

Acyclic 1,4-dicarbonyl compounds

Acylation 5-dicarbonyl compounds

Aldosuloses and Other Dicarbonyl Compounds

Alkylation of 3-dicarbonyl compounds

Alkylation of p-dicarbonyl compounds

Allylation 1,3-dicarbonyl compounds

Allylation preparation of 1,4-dicarbonyl compounds

Amine-Catalyzed Cascade Reactions of Ketoses with 1,3-Dicarbonyl Compounds

Amines reactions with dicarbonyl compounds

Amino sugars 3-dicarbonyl compounds

Amino sugars reaction with /1-dicarbonyl compounds

Aniline derivatives dicarbonyl compounds

Aqueous 1,3-dicarbonyl compounds

Arginine reaction with dicarbonyl compound

Benzene with 1,2-dicarbonyl compounds

Benzyliden-1,3 -dicarbonyl compounds

Beta-dicarbonyl compounds

COPPER CATALYZED ARYLATION 0-DICARBONYL COMPOUNDS

Carbonyl compound dicarbonyl

Conjugate addition of 1,3-dicarbonyl compounds

Cyclization of 1.5-dicarbonyl compound

Cyclizations 4+3] Cycloadditions, 1,4-dicarbonyl compounds

Deoxy dicarbonyl compound

Detection dicarbonyl compounds

Diazomethane reaction with 1,2-dicarbonyl compounds

Diazotates 3-Dicarbonyl compounds

Dicarbonyl Compounds Claisen Condensations

Dicarbonyl Compounds and their Derivatives

Dicarbonyl Compounds as Nucleophiles

Dicarbonyl Compounds by Acylation of Ketone Enolates

Dicarbonyl Compounds with a-Amino Acids

Dicarbonyl Compounds, The Photochemistry of (Monroe)

Dicarbonyl Compounds, frames

Dicarbonyl and Related Compounds

Dicarbonyl compound aldol reactions with

Dicarbonyl compound reductions yeast

Dicarbonyl compound, reductive

Dicarbonyl compound, reductive coupling

Dicarbonyl compounds 2,4-disulfide

Dicarbonyl compounds Carbon dioxide

Dicarbonyl compounds Copper oxide

Dicarbonyl compounds Diacids

Dicarbonyl compounds Diketones

Dicarbonyl compounds Hexamethylphosphoric triamide

Dicarbonyl compounds Iodine

Dicarbonyl compounds Iodosylbenzene

Dicarbonyl compounds Iron carbonyl

Dicarbonyl compounds Keto amides

Dicarbonyl compounds Keto esters

Dicarbonyl compounds Knoevenagel reaction

Dicarbonyl compounds Methyl acetoacetate

Dicarbonyl compounds Methyl vinyl ketone

Dicarbonyl compounds Ozone

Dicarbonyl compounds Tebbe reagent

Dicarbonyl compounds Zinc chloride

Dicarbonyl compounds by oxidation

Dicarbonyl compounds decarboxylation

Dicarbonyl compounds fluorination

Dicarbonyl compounds from Claisen condensation

Dicarbonyl compounds malonates

Dicarbonyl compounds methylenation

Dicarbonyl compounds monoanions

Dicarbonyl compounds monoprotection

Dicarbonyl compounds product

Dicarbonyl compounds pyridones

Dicarbonyl compounds quinolines

Dicarbonyl compounds reaction with hydroxylamine

Dicarbonyl compounds reactions

Dicarbonyl compounds retrosynthetic analysis

Dicarbonyl compounds succinic anhydride

Dicarbonyl compounds tautomers

Dicarbonyl compounds, a-selenooxidative syn elimination

Dicarbonyl compounds, a-selenooxidative syn elimination synthesis

Dicarbonyl compounds, addition

Dicarbonyl compounds, addition reactions

Dicarbonyl compounds, addition transition metal complexes

Dicarbonyl compounds, aldol reactions

Dicarbonyl compounds, reduction

Dicarbonyl compounds, tautomerism

Dicarbonyl type compounds

Dicarbonyls 1,3-compounds

Dicarbonyls 1,3-compounds

Diels-Alder reaction 1,6-dicarbonyl compounds

Enamines dicarbonyl compound monoprotection

Enol ethers from 1,3-dicarbonyl compounds

Enolates 1.3- dicarbonyl compounds

Enolates of /3-dicarbonyl compounds

Enolates p-dicarbonyl compounds

Enols from 1,3-dicarbonyl compounds

Fi-dicarbonyl compound

From 1,3-Dicarbonyl Compounds and Ketones

From 1,5-Dicarbonyl Compounds

From l-Dicarbonyl Compounds

Fructose dicarbonyl compounds

Fructose reaction with dicarbonyl compounds

Ft-dicarbonyl compounds

Glyceraldehyde reaction with 1,3 dicarbonyl compounds

Glycoses, amino, reaction with /3-dicarbonyl compounds

Glycosylamines, reaction with /3-dicarbonyl compounds

Henry reaction 6-nitro-l,3-dicarbonyl compounds

Iron compounds Dicarbonyl

Isoxazoles from 1,3-dicarbonyl compound

J8-dicarbonyl compounds

Macrocyclic complexes with ligands based on 1,3-dicarbonyl compounds and 1,2- or 1,3-diamines

Methylene bis-dicarbonyl compounds

Methylene-1,3-dicarbonyl compound

Michael addition Of 1,3-dicarbonyl compounds

Monoprotection of Dicarbonyl Compounds

Other Dicarbonyl Compounds

Oxidation of Dicarbonyl Compounds to Carboxylic Acids

Oxidation of Ketones to a-Dicarbonyl Compounds

P-Dicarbonyl compounds

Phosphorylation 3-dicarbonyl compounds

Propanone dicarbonyl compounds

Pyrans from 1,3-dicarbonyl compounds

Pyrazines from 1,2-dicarbonyl compound

Pyridines from 1,3-dicarbonyl compound

Pyrimidines can be made from 1,3-dicarbonyl compounds and amidines

Pyrimidines from 1,3-dicarbonyl compound

Pyrrole synthesis, from 1,4-dicarbonyl compound

Pyrroles preparation from dicarbonyl compounds

Pyrroles, thiophenes, and furans from 1,4-dicarbonyl compounds

Pyryliums from 1,3-dicarbonyl compounds

Quinones and 1,2-Dicarbonyl Compounds (1,4-Dioxabutadienes)

Reaction of a,3-Dicarbonyl Compounds with Ammonia

Reduction of Functionalized Carbonyl and Dicarbonyl Compounds

Reductive cyclization dicarbonyl compounds

Retrosynthesis of 1,5-Dicarbonyl Compounds

Silylenes dicarbonyl compound monoprotection

Specific enol equivalents from 1,3-dicarbonyl compounds

Sulfinyl compounds, l,3-dicarbonyl-2-phenylpyrolysis

Syntheses Using 3-Dicarbonyl Compounds

Tautomeric 1,3-dicarbonyl compounds

Thioacetal-protected dicarbonyl compound

Thiophene, from 1,4-dicarbonyl compound

Thiophenes dicarbonyl compounds

Thiophenes preparation from dicarbonyl compounds

Unsaturated dicarbonyl compound

Vicinal dicarbonyl compounds

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