Diazoxide interaction

Hydralazine (Apresoline/ Others) [Antihypertensive/ Vasodilator] Uses Mod-severe HTN CHF (w/ Isordil) Action Peripheral vasodilator Dose Adults. Initial 10 mg PO qid, T to 25 mg qid 300 mg/d max Peds. 0.75-3 mg/kg/24 h POq6—12h -i in renal impair V CBC ANA before Caution [C, +] -1- Hqjatic Fxn CAD T tox w/ MAOI, indomethacin, BBs Contra Dissecting aortic aneurysm, mitral valveAheumatic heart Dz Disp Tabs, inj SE SLE-like synd w/ chronic high doses SVT following IM route, p ipheral neuropathy Interactions T Effects W/ antih5 pertensives, diazoxide, diuretics, MAOIs, nitrates. 

Profound hjrpotension, resulting in renal insufficiency, has been reported in a single patient after the administration of atenolol 100 mg orally (51) however, large doses of furosemide and diazoxide were also given in this case, and this appears more likely to have been a consequence of a drug interaction. 

Clinically important, potentially hazardous interactions with amprenavir, aprepitant, bedomethasone, buprenorphine, calcium, chloramphenicol, cimetidine, dobazam, clorazepate, cyclosporine, cyproterone, darunavir, dasatinib, delavirdine, dexamethasone, diazoxide, disulfiram, dopamine, fesoterodine, fluconazole, flunisolide, fluoxetine, fosamprenavir, ginkgo biloba, hydrocortisone, imatinib, indinavir, influenza vaccines, isoniazid, isradipine, itraconazole, lacosamide, lapatinib, lopinavir, meperidine, methylprednisolone, midazolam, mivacurium, nelfinavir, nilotinib, nilutamide, phenylbutazone, piracetam, posaconazole, prednisolone, prednisone, primrose, ritonavir, rivaroxaban, sage, saquinavir, solifenacin, St John s wort, sucralfate, telithromycin, temsirolimus, teniposide, ticlopidine, tizanidine, tolvaptan, triamcinolone, uracil/tegafur, vigabatrin... 

K. D. Garlid, P. Paucek, V. Yarov-Yarovoy, H. N. Murray, R. B. Darbcnzio, A. J. D Alonzo, N. J. Lodge, M. A. Smith and G. J. Grover, Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitivc K+ channels possible mechanism of cardioprotection, Circ Res 81,1072-1082, (1997). 

C, +] i Hepatic Fxn CAD T tox w/ MAOI, indometliacin, BBs Contra Dissecting aortic anernysm, mitral valve/rheumatic heart Dz Disp Tabs, inj SE ST E-like synd w/ clrronic higli doses SVT following EM route, peripheral neuropatlry Interactions T Effects W/ antihypertensives, diazoxide, dimetics, MAOIs, nitrates. 

Eq. (c) illustrates the interaction of (III) with ethyl ortho-acetate in the presence of acetic acid to obtain the desired compound, diazoxide, with the elimination of three moles of ethanol. 

A child receiving phenytoin 29 mg/kg daily and an adult receiving phenytoin 1 g daily were unable to achieve therapeutic phenytoin serum levels while taking diazoxide. When the diazoxide was withdrawn, satisfactory serum phenytoin levels were achieved with dosages of only 6.6 mg/kg and 400 mg daily, in the child and the adult, respectively. When diazoxide was restarted experimentally in the adult, the serum phenytoin levels became undetectable after 4 days, and seizures occurred. Two other reports describe this interaction. " In addition it appears that the effects of the diazoxide can also be reduced. ... 

Information is limited to these reports, but the interaction would appear to be established. Monitor the effects of concurrent use, being alert for the need to increase the phenytoin dosage. The clinical importance of the reduced diazoxide effects is uncertain. 

Roe TF, Podosin RL, Blaskovics ME. Drug Interaction diazoxide and dipher lhydantoiiL J... 

Petro DJ, Vannucci RC, Kulin HE. Diazoxide-diphenylhydantoin interaction. (1976)... 

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