Diamine treatments

In comparative studies, [ C]toluene 2,4-diamme, the hydrolysis product of [ ]-toluene 2,4-diisocyanate, was administered to rats at doses of 3 mg/kg bw (orally or intravenously) and 60 mg/kg bw orally. After 48 h, the distribution of radioactivity was similar in all cases (urine, 64-72% faeces, 20-31% and tissue/carcass/gastrointestinal tract, 2-5%). Comparison of the toluene 2,4-diisocyanate inhalation group with the oral toluene 2,4-diisocyanate and toluene 2,4-diamine treatment groups indicated that a larger percentage of the inhaled radioactivity was in the tissues/carcass and that excretion of radioactivity into the urine was slower following toluene 2,4-diisocyanate inhalation. 

The unusual 1,2,3-benzoxathiazole (14) was prepared by Tl(III) oxidation of the bis(tosyl-amide) of 4-bromobenzene-l,2-diamine treatment of the sulfonamidines (188) with KOBu to give the 1,2,3-oxathiazolines (189) is a related reaction. 

Polyamides from diamines and dibasic acids. The polyamides formed from abphatic diamines (ethylene- to decamethylene-diamine) and abphatic dibasic acids (oxabc to sebacic acid) possess the unusual property of forming strong fibres. By suitable treatment, the fibres may be obtained quite elastic and tough, and retain a high wet strength. These prpperties render them important from the commercial point of view polyamides of this type are cabed nylons The Nylon of commerce (a 66 Nylon, named after number of carbon atoms in the two components) is prepared by heating adipic acid and hexamethylenediamine in an autoclave ... 

The diacid-diamine amidation described in reaction 2 in Table 5.4 has been widely studied in the melt, in solution, and in the solid state. When equal amounts of two functional groups are present, both the rate laws and the molecular weight distributions are given by the treatment of the preceding sections. The stoichiometric balance between reactive groups is readily obtained by precipitating the 1 1 ammonium salt from ethanol ... 

The final reduction product of pyrazine, piperazine (89), is a stable compound which behaves as a typical diamine. It has found extensive use in medicinal chemistry as a linking agent and as a medicine in its own right for the treatment of helminths both in human and veterinary medicine. 

The same diamine, when treated with carbon disulfide in alkaline medium, yielded 2-mercapto- l//-imidazo[4,5-/]quinoline (88PS267,88SC973,86IJC264), which, on treatment with alkyl, aralkyl, and acid halides, gave the corresponding thioethers and thioesters 111, respectively (88PS267, 86IJC264). 

Treatment of 434 with Al,iV -dimethylpropane-1,3-diamine gave a complex mixture, from which the product of possible denitrocyclization reaction 488 was obtained in 51% yield (Eq. 46) (95BCJ3227). 

Treatment of the heterocycle, 38 (obtained from ethylene-diamine and carbon disulfide), with nitrous acid affords the N-nitroso compound, 39. Reduction with zinc leads to the corre-... 

One scheme for preparation of the diamine side chain consists in first reducing the carbonyl group of the haloketone, 73. Displacement of the halogen with diethylamine gives the amino alcohol (74). Treatment of that intermediate with thionyl bromide serves to replace the hydroxyl by bromine (75). The synthesis is completed by displacement of the bromine with ammonia. 

Treatment of 2,6-dimethylaniline (121) with phosgene and triethylamine affords the corre-S]ionding isocyanate (122). Condensation of that reactive intermediate with N-isopropylpropyl-cne-1,3-diamine leads to formation of urea 123. This product, recainam (123), acts as membrane Stabilizing agent and thus exhibits both local anesthetic and antiarrhythmic activity [30]. 

Amino-77/-dibenz[/),t/]azepin-7-ones, e.g. 7, prepared either by successive bromination, aminodebromination, and dehydrogenation of 5-tosyl-5A/-dihydro 7>,t/]azepin-7(6//)-ones, or by the oxidation of 6-ethoxy-6,7-dihydro-5//-dibenz 7>,r/]azepincs with lead(IV) acetate followed by aminodemethoxylation, on treatment with a bidentate nucleophile (e.g.. benzene-1,2-diamine or 2-aminobenzenethiol) yield the pentacyclic systems 8 and 9, respectively.27... 

Diazotization of biphenyl-2,2 -diamine, followed by treatment with aqueous ammonia, gives the parent compound la.331 A number of analogs lb-d, prepared in the same way. are all unstable oils.331... 

Pimelic Acid (Heptanedioic Acid or 1,5-Pentane-dicarboxytlc Acid). HOOC.(CH2)s.COOH mw 160.17 white prisms mp 106° bp 272° at 100mm (subl), and 212° at 10mm d 1.329 g/cc at 15°. Sol in w, ethanol, eth and hot benz. Prepn is by oxidn of cycloheptanone, capric acid or oleic acid treatment of salicylic acid with Na in amyl ale, or by decarboxylating 1,1,5,5-pentanetetracarboxylic acid with heat Pimelic acid has been combined with cis and trans-, 4-cyclohexanediol to give polyesters, and with m-xylene-ce,ol -diamine or poly-methylenediamines to form polyamides. With diperoxides, the acid forms resins. It is also used as the parent compd to form the expls presented below... 

Because of their surfactant and filming properties fatty amines such as coco-alkylamine acetate (and more especially diamines, such as tallow propylenediamine) are also occasionally employed in other types of water treatment programs. For example, they may be used as corrosion inhibitors for steel cooling systems, especially those smaller units where minimal operational control is provided. The amines must be continuously dosed to ensure good film formation (and thus corrosion protection), typically at 5 to 10 ppm active amine. They also tend to have good biostatic control properties, which provide a benefit of algal and bacterial control at no extra cost. 

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