Diabetes effects drug metabolism

Sugar is one of the purest foods made, from natural sources, and has never been known to contain any toxic or harmful components. Intensive investigations by the U.S. Food and Drug Administration resulted in a book in 1986 on the health and safety factors of sugar (cane and beet) in the diet (18). The conclusion was that sugar has no deleterious effect on health in regard to heart disease, diabetes, or other metabolic disorder. 

Drug of choice among intravascular agents more effective for glaucoma with inflammation than urea or glycerol Contraindicated in patients with renal disease caution in hepatic impairment Safe to use in diabetic patients (not metabolized to provide calories),... 

Skett, P., R.A. Cochrane, and L.A. Joels (1984). The role of androgens in the effect of diabetes mel-litus on hepatic drug metabolism in the male rat. Acta Endocrinol. 107, 506-512. 

Rouer, E., A. Lemoine, T. Cresteil, P. Rouet, and J.P. Leroux (1987). Effects of genetically or chemically induced diabetes on imipramine metabolism. Respective involvement of flavin monooxygenase and cytochrome P450-dependent monooxygenases. Drug Metab. Dispos. 15, 524-528. 

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