Dextran sulphate inhibitory effect

The anti-HSV-1 activity of Ca-SP was assessed by plaque yield reduction and compared with those of dextran sulphate as a representative sulphated PS. These data indicate that Ca-SP is a potent antiviral agent against HSV-1, as even at low concentrations of Ca-SP, no enhancement of virus-induced syncytium formation was observed, as occurred in dextran sulphate-treated cultures. Reeently, Lee et al. [73] investigated the effects of structural modifications of Ca-SP on antiviral activity. Calcium ion binding with the anionic part of the molecule was replaeed with various metal cations, and their inhibitory effects on the replication of HSV-1 were evaluated. Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity, while divalent and trivalent metal cations reduced the activity. Depolymerization of sodium spirulan with hydrogen peroxide decreased the antiviral activity as its molecular weight decreased. 

In rat-foot oedema tests, chloroquine sulphate in intraperitoneal doses of 10 mg/kg twice daily two days before and immediately prior to a formalin injection was found to be ineffective , whereas other workers have found chloroquine inhibitory in oral doses of 50 mg/kg . In these latter tests mepacrine, proguanil and primaquine, in oral doses of 50 mg/kg, were also effective. Chloroquine sulphate in doses of 10 mg/kg twice daily intraperitoneally for short or long term administration does not affect the development of generalized oedema produced by intraperitoneal dextran or egg-white . When administered chronically it reduces skin inflammation produced locally by chloroform, but is less effective than salicylates . ... 

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