Dextran immunogenicity

The attachment of carbohydrate to proteins has also been used as a means of prolonging the survival of proteins in the circulation. The attachment of dextran to alpha amylase, catalase7 (EC 1.11.1.6), arginase (EC 3.5.3.1), and carboxypeptidase G (EC 3.4.12.10)158 prolonged their serum half-lives in rats and mice. The attachment of dextran presumably diminished the susceptibility of the conjugates to proteolysis, uptake by the reticuloendothelial system, and filtration by the kidney. The immunogenicity of alpha amylase and catalase was also considerably lessened, although not entirely eliminated.7... 

Dextran is a physiologically harmless biopolymer because of its biocompatible, biodegradable, non-immunogenic and non-antigenic properties [54, 55]. It can be depolymerised by different a-l-glycosidases (dextranases) occurring in liver, spleen, kidney and lower part of the gastrointestinal tract. 

Fagnani R, Hagan MS, Bartholomew R (1990) Reduction of immunogenicity by covalent modification of murine and rabbit immunoglobulins with oxidized dextrans of low molecular weight. Cancer Res 50 3638-3645... 

Allergy to icodextrin was the most likely explanation for the severe cutaneous reaction. The epitope(s) for allergic reactions to dextrans have not been defined, although they are undoubtedly immunogenic. It is possible that the same or a similar epitope may be responsible for allergic reactions to icodextrin. 

Dextran (O Scheme 5) solutions have been used as a plasma volume expander since 1947 owing to their non-immunogenic and well-tolerated nature as plasma substitutes [10]. Furthermore, since dextran suppresses erythrocyte aggregation and reduces blood viscosity, it has... 

Lees, A., et al.. Enhanced immunogenicity of protein-dextran conjugates I. Rapid stimulation of enhanced antibody responses to poorly immunogenic molecules. Vaccine, 1994, 12, 1160-1166. 

Crepon, B. Jozeeonvicz, J. Chytry, V. Rihova, B. Kopecek, J. Enzymatic degradation and immunogenic properties of derivatized dextrans. Biomaterials 1991,12 (6), 550-554. 

Gibbons R, Banghart S (1967) Synthesis of extracellular dextran by cariogenic bacteria and its presence in human dental plaque. Arch Oral Biol 12 11-24 Gill TJ, Kunz HW (1968) The immunogenicity of vinyl polymers. Proc Natl Acad Sci USA 61 490-496... 

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