Dexedrine

Enantiomer I, called Dexedrine, is by far the stronger stimulant. It is from two to four times as active as Benzedrine, the racemic mixture of the two isomers. 

Denatured ethanol, 592 Density The ratio of the mass of a substance to its volume, 14-15 measuring, 14-15 electron, in hydrogen atom, 165 lipoprotein, 603-604 measuring, 14-15 molar mass and, 109-111 Dexedrine, 601 Diabetes, 593... 

The amphetamines, such as amphetamine, dextroamphetamine (Dexedrine), and metliainphetainine (Desoxyn), are sympatiiomimetic (ie, adrenergic) dru that stimulate the CNS (see Chap. 22). Their drug action results in an elevation of blood pressure, wakefulness, and an increase or decrease in pulse rate The ability of these drugs to act as anorexiants and suppress the appetite is thought to be due to their action on the appetite center in the hypothalamus. 

Amphetamines (speed sulph, sulphate, uppers, wake-ups, billy whizz, whizz, whites, base) are synthetic stimulants which as medicines have been formed into a variety of tablets. Their current medical use is very limited and in fact only dexamphetamine sulphate, Dexedrine, is now available for use solely in the treatment of narcolepsy. The only other amphetamine available for medical use is methylphenidate (Ritalin) for the treatment of attention deficit syndrome in children. As a street drug, amphetamine usually comes as a white, grey, yellowish or pinky powder. The purity rate of street powders is less than 10%, the rest being made up of milder stimulants such as caffeine, other drugs such as paracetamol or substances like glucose, dried baby milk, flour or talcum powder. 

Dextroamphetamine (Dexedrine) Intermedia te- acting 2.5-5 mg every morning T 2.5-5 mg/day in weekly intervals 5-20 mg twice daily (40 mg/day)... 

Blyth, C. S., Allen, E. M., and Lovingood, B. W., Effects of amphetamine (dexedrine) and caffeine on subjects exposed to heat and exercise stress, Research Quarterly, 31, 553, 1960. 

Compared to the 2- hour duration of the subjective effects of natural marijuana, the effects of a mixture of the eight isomers of this synthetic derivative lasted much longer - up to 30 hours. We gave some Dexedrine to the above subject to see if it would reduce or shorten his symptoms. Not surprisingly, his alertness improved but all the other effects persisted unchanged. 

Although I had to drive 25 miles to reach his trailer, the results of treatment were gratifying. Providing him with Dexedrine and psychotherapy for a few months produced remarkable improvement. Not only could he go out for short walks, but he also reported with pride that he had resumed having sex with his wife. 

Methylphenidate (Ritalin), dextroamphetamine (Dexedrine), and pemoline (Cylert) are currently available in the United States. Methylphenidate has been the most widely used and is usually the first choice. Pemoline sometimes impairs liver function and is rarely used today due to the potential for toxicity. 

Dextroamphetamine (Dexedrine). Dextroamphetamine is the second most widely used stimulant and the most commonly used amphetamine in the United States. It is about twice as potent as methylphenidate and should be initiated in the treatment of ADHD at 2.5 mg taken twice daily with breakfast and lunch. Like other stimulants, the benefits of dextroamphetamine can be seen almost immediately. With weekly visits while starting treatment, the dose can be increased in 2.5-5 mg increments until the effective dose is found. Because dextroamphetamine is also slightly longer acting than methylphenidate, patients may be less likely to need an evening dose. If an after-school dose is used, then like methylphenidate it should be 25-50% of the daytime dose. 

Dextroamphetamine (Dexedrine) is commonly initiated at 5 mg taken two to three times daily before meals. Many patients will experience its benefits almost from the first day. The dose can be increased every 5-7 days until the effective dose is found. 

Stimulants. Methylphenidate (Ritalin) and dextroamphetamine (Dexedrine) are the most widely used and perhaps the most effective medications when treating post-TBI apathy. They act by enhancing the activity of dopaminergic, noradrenergic and, to a certain extent, serotonergic brain systems. Stimulants act quickly to relieve the core symptoms of apathy, and they may also improve the impairments in attention and short-term memory that often follow TBl. Please refer to Chapter 8 for more information about the stimulants. 

Tablets 5 mg c-ii) Various, Dexedrine (GlaxoSmithKline), Dextrostat (Shire Richwood)...

In 2001, Celgene obtained FDA approval to re-launch the single enantiomer dexmethyl-phenidate d-threo 2, formerly Dexedrine ) for ADHD under the brand name Focalin , and subsequently sold the product to Novartis, d-threo Methylphenidate has a 2.2 h... 

Many psychomotor stimulants possess activities similar to those of amphetamine and have been discussed previously (see Chapter 10). Of primary importance to our discussion of the psychomotor stimulants are amphetamine Adderall, Benzedrine, Dexedrine), methampheta-mine (Desoxyn), and methylphenidate (Concerta, Ritalin, Metadate, Methylin). 

Brand Name(s) Dexedrine, Dexedrine Spansule, Dextrostat Chemical Class D-p-phenyhisopropylamine... 

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