Dexamethasone synthase induction

R4. Rees, D. D., Cellek, S Palmer, R. M. J., and Moncada, S., Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone An insight into endotoxin shock. Biochem. Biophys. Res. Commun. 173,541-547 (1990). 

Thaliporphine was observed to inhibit the formation of nitrites/nitrates caused by lipopolysaccharide (LPS) in J774.2 macrophages. This inhibition was similar to that produced by cycloheximide, A -methyl-L-arginine and dexamethasone. The results of these and other studies in this report demonstrated that thaliporphine inhibited LPS induction of NO synthase expression, and that the mechanism of action of the alkaloid was via inhibition of LPS-stimulated interleukin-ip synthesis in macrophages. Pretreatment of anesthetized rats with thaliporphine... 

Penrella, J.A., Yoshizumi, M., Fen, Z., Tsai, J.-C., Hsieh, C.-M., Kourembanas, S., and Lee, M.-E. (1994). Transforming growth factor-Pl, but not dexamethasone, downregulates nitric-oxide synthase mRNA after its induction by interleukin-1P in rat smooth muscle cells. J. Biol. Chem. 269 14595-14600. 

Kujubu DA, Herschman HR. Dexamethasone inhibits mitogen induction of the TISIO prostaglandin synthase/cyclooxygenase gene. J Biol Chem 1992 267 7991-7994. 

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