Organophosphates developmental toxicity

Data concerning developmental toxicity in animals are very limited, and are at best suggestive that elicitation of developmental effects by some organophosphate ester hydraulic fluids may occur in some animals. The developmental toxicity data are too sparse to make any conclusions regarding their relevance to human health. 

Tri-o-cresyl phosphate, not classified as a pesticide, is the only organophosphate for which testing and a final report were to have been completed in 1986. One of the TOCP studies under the auspices of CDC/NIOSH, and with an A completion priority, was a reproductive/developmental toxicity study. However, it is unclear from the TOCP listings (ref. 172a, Table 23) whether either the reproductive study or one of the neurologic/behavioral studies for TOCP was completed and reported in 1986. 

Slotkin, T.A., Levin, E.D. and Seidler, F.J. (2006) Comparative developmental neurotoxicity of organophosphate insecticides effects on brain development are separable from systemic toxicity. Environ. Health Perspect., 114 (5), 746-751. 

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