Development of liquid chromatography

Review of the Development of Liquid Chromatography/Mass Spectrometry... 

Recent and future developments of liquid chromatography in pesticide trace analysis Hogendoorn, E. Van Zoonen, P. J. Chromatogr., A 2000, 892, 435-453. 

The development of liquid chromatography on a chiral support gave a decisive impulse to the study of atropisomerism since resolution can be quantitatively performed under very mild conditions without derivatiza-tion. The analytical methods can be easily extrapolated to preparative scale. Several atropisomeric systems, which do not present suitable functional groups to perform classical resolution through diastereomer resolution, can be readily separated into optically pure enantiomers. Dynamic chiral HPLC fills the gap between barriers attainable by DNMR and by thermal racemization of pure enantiomers. Chiral HPLC opens the way to several unexplored domains in the field of atropisomerism. We have... 

Fall-out from the considerable activity in the development of liquid chromatography systems has shown itself in some of the latest experimental variations for conducting preparative TREF. In addition to the use of valves, tubing, fittings and pumps normally associated with LC systems, progratmned ovens have also... 

Ashcroft, A.E., Herod, A.A., Manton, G. (1988) Applications and further developments of liquid chromatography-fast atom bombardment mass spectrometry (LC-FAB-MS) using a continuous flow probe. In Proceedings of the 36th ASMS Conference on Mass Spectrometry and Allied Topics, June 5-10, San Francisco, CA. 

Recently, UHPLC-MS has become the mainstream of development of liquid chromatography, which has been successfully applied to many fields, including rapid qualification and quantification of traditional Chinese medicine, metabonomics, drug metabolism, and pharmacokinetics study. 

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