Development and Scope

7-octadien-l-ol is a highly reactive compound having double bonds and a hydroxyl group. Reacting this compound in the presence of a copper chromite catalyst at a temperature of 220 °C causes intramolecular dehydrogenation/hydroge-nation, to yield isomerized 7-octenal in a yield of at least 80 % [12]. This aldehyde 

Telomerization with formic acid as a telogen can produce 1,7-octadiene, which is useful as a modifier for polyolefins. This reaction proceeds with the same system that is used for the production of octadienol [14], at a temperature of 50-70°C, to yield l,7-octadiene/l,6-octadiene in a ratio of 88 12. Since these compounds phase-separate together, the product layer can be readily separated and the sulfolane layer containing the catalyst can be circulated for re-use. 

The first catalytic cyclodimerization of 1,3-butadiene (BD) to 1,5-cycloocta-diene using modified Reppe catalysts was reported by Reed in 1954 [4], and only two years later Wilke reported on the titanium-catalyzed synthesis of cyclo-dodecatrienes from BD [5]. It remained for Wilke and his co-workers to show the tremendous versatility and scope of the nickel-catalyzed cyclooligomerizations of 

3-dienes [6]. The elucidation of the reaction mechanism led to isolation of intermediates (7 -allylnickel complexes), which stimulated research into nickel organic chemistry as well as into catalysis [6b,e]. 

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As a chemist, I should briefly discuss what my field of science is. Here 1 also reflect on its historical development and scope, which help to put in perspective the broad background on which our contemporary chemistry was built, and where my own work fits in. 

Avidan, A.A. Origin, development and scope of FCC. In Fluid Catalytic Cracking Science and Technology, Magee, J.S., Mitchell, M.M., Eds. Studies in Surface Science and Catalysis Elsevier, 1993 Vol. 76. 

Liegault B, Lee D, Huestis MP, Stuart DR, Fagnou K (2008) Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air reaction development and scope. J Org Chem 73 5022-5028... 

The polymerase chain reaction (PCR) is the most widely used technique for oligonucleotide synthesis. Microchips/microdevices for PCR are studied extensively, and thus great progress has been made in the development and scope of microchip components of microchip-based PCR analyzers such as on-chip micromachining (fabrication, bonding, and sealing), choice of... 

Abstract Development and scope of conventionally difficult molecular transformation on site-selective acylation of carbohydrates and polyol compounds are described. A salient feature is that the site-selectivity can be controlled independently from the intrinsic reactivity of the substrate, i.e., catalyst-controlled selectivity. Therefore, some substrates undergo acylation with reversal of their intrinsic reactivity. The mechanistic aspects of catalyst-controlled site-selective acylation are discussed with the emphasis on the strategy relying on the accelerative reaction rather than the decelerative one. An unconventional retrosynthetic route based on catalyst-controlled site-selective acylation is proposed toward extremely short-step total synthesis of natural glycosides of an ellagitannin family. Application to the late-stage functionalization of the complex natural products of biological interest is also described. 

M. Dolg, X. Cao. Relativistic Pseudopotentials Their Development and Scope of Applications. Theor. Chem. Acc., 112 (2012) 403 80. 

The combination of rhodium catalysts and organoboronic acids has emerged recently as a powerful and ideal catalytic system in carbon-bond forming reactions. This tremendous system overcomes the functional group protection issue, but can also apply to catalytic asymmetric synthesis, which can provide much chiral product using a small amount of a chiral catalyst. This chapter reviews the development and scope of the rhodium-catalyzed addition of boronic acids to organic electrophiles [1]. 

Dolg M, Cao X (2011) Relativistic pseudopotentials their development and scope of... 

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