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Detoxication with active sulfate

Reactions of biotransformation of xenobiotics are usually divided into Phase I and Phase II reactions. In Phase I reactions a polar group, such as hydroxyl (-OH), carboxyl (-COOH), thiol (-SH) and amino (-NH2) group, is introduced into the molecule through the reactions of oxidation, reduction and hydrolysis. Metabolites formed can be more toxic than parent compounds (i.e. paraoxon compared to parathion), but some other nontoxic metabolites can be formed as well. In Phase II reactions polar metabolites are conjugated with endogenous substrates such as glucuronides, sulfates, acetates and amino acids, which form hydrosoluble products that can be readily excreted in urine. However, in the case of OPC it is acceptable to divide reactions of biotransformation to activation and detoxication processes. In these metabolic processes significant role have diflerent enzyme... [Pg.248]


See other pages where Detoxication with active sulfate is mentioned: [Pg.463]    [Pg.118]    [Pg.184]    [Pg.156]    [Pg.75]    [Pg.143]    [Pg.320]    [Pg.429]    [Pg.140]    [Pg.395]    [Pg.102]    [Pg.308]    [Pg.187]    [Pg.466]    [Pg.44]    [Pg.253]   
See also in sourсe #XX -- [ Pg.104 ]




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Active sulfate

Detoxication

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