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Focused/diverse library design

Focused/Diverse Library Design Using Pharmacophore Fingerprints... [Pg.194]

The use of 3D pharmacophore fingerprints in CADD applications can be broadly classified into the areas of design of combinatorial focused/diverse libraries, analyzing ligand-protein interactions and virtual HTS (vHTS) and protein selectivity. [Pg.194]

R.A. Lewis, The design of small- and medium-sized focused combinatorial libraries design of focused combinatorial libraries, in Molecular Diversity in Drug Design, P.M. Dean and R.A. Lewis (eds), Kluwer Academic Publishers, Dordrecht, 1999, 221. [Pg.182]

Young, S.S. and Ge, N., Design of diversity and focused combinatorial libraries in drug discovery, Curr. Opin. Drug Disc. Dev., 2004, 7, 318-324. [Pg.78]

Reynolds CH (1999) Designing diverse and focused combinatorial libraries of synthetic polymers. J Comb Chem 1 297-306... [Pg.15]

More recently, the focus has moved from diversity in favor of combinatorial libraries designed to target specific receptors or enzymes (12). While these single-target-focused libraries remain a key component of many drug-discovery programs, and are useful in both hit to lead and lead optimization contexts,... [Pg.355]

See other pages where Focused/diverse library design is mentioned: [Pg.183]    [Pg.364]    [Pg.368]    [Pg.183]    [Pg.364]    [Pg.368]    [Pg.381]    [Pg.50]    [Pg.318]    [Pg.30]    [Pg.230]    [Pg.278]    [Pg.194]    [Pg.204]    [Pg.223]    [Pg.1008]    [Pg.734]    [Pg.315]    [Pg.354]    [Pg.356]    [Pg.30]    [Pg.97]    [Pg.179]    [Pg.179]    [Pg.182]    [Pg.183]    [Pg.184]    [Pg.185]    [Pg.189]    [Pg.189]    [Pg.191]    [Pg.405]    [Pg.423]    [Pg.423]    [Pg.2]    [Pg.129]    [Pg.65]    [Pg.335]    [Pg.336]    [Pg.355]    [Pg.355]    [Pg.367]    [Pg.373]   
See also in sourсe #XX -- [ Pg.183 ]



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Design diversity

Diverse libraries

Diversity library

Focused design

Focused libraries

Library design

Library design focused

Library design focusing

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