Dermal substitutes split-skin graft

The biomaterials tested exhibited successful integration, confirming results of previous studies, and the partial wound epithelialisation was achieved by day 21 where either split-thickness skin graft or cultured keratinocytes were applied over dermal substitute biomaterial (Figs. 25.2 and 25.3). 

Fig. 25.2 Survival of a split-thickness skin graft applied over Permacol paste. SSG day 0, assessed 6 days post grafting, haematoxylin and eosin, xlOO. Epithelium of a split-thickness skin graft (SSG) was viable and well-structured. Dermal component of the graft was intimately attached to the well-cellularised Permacol paste PP) with minimal signs of the inflammatory reaction. Dermal substitute biomaterial integrated into the full-thickness wound via granulation tissue in growth present at the paste and wound bed (WB) interface...

Nguyen DQ, Potokar TS, Price P. An objective long-term evaluation of Integra (a dermal skin substitute) and split thickness skin grafts, in acute bums and reconstructive surgery. Bums 2010 36 23-8. 

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